Reversible atransferrinemia in a patient with chronic enteropathy: is transferrin mandatory for iron transport?

Herein, we report the case of a 42-year-old woman, hospitalized in a French tertiary hospital for a relapse of a chronic enteropathy, who was found on admission to have no detectable serum transferrin. Surprisingly, she only exhibited mild anaemia. This atransferrinemia persisted for two months thro...

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Detalles Bibliográficos
Autores principales: Raynor, Alexandre, Stefanescu, Carmen, Bruneel, Arnaud, Puy, Hervé, Peoc’h, Katell, Manceau, Hana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Croatian Society of Medical Biochemistry and Laboratory Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807235/
https://www.ncbi.nlm.nih.gov/pubmed/36627980
http://dx.doi.org/10.11613/BM.2023.010801
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author Raynor, Alexandre
Stefanescu, Carmen
Bruneel, Arnaud
Puy, Hervé
Peoc’h, Katell
Manceau, Hana
author_facet Raynor, Alexandre
Stefanescu, Carmen
Bruneel, Arnaud
Puy, Hervé
Peoc’h, Katell
Manceau, Hana
author_sort Raynor, Alexandre
collection PubMed
description Herein, we report the case of a 42-year-old woman, hospitalized in a French tertiary hospital for a relapse of a chronic enteropathy, who was found on admission to have no detectable serum transferrin. Surprisingly, she only exhibited mild anaemia. This atransferrinemia persisted for two months throughout her hospitalization, during which her haemoglobin concentration remained broadly stable. Based on her clinical history and evolution, we concluded to an acquired atransferrinemia secondary to chronic undernutrition, inflammation and liver failure. We discuss the investigations performed in this patient, and hypotheses regarding the relative stability of her haemoglobin concentration despite the absence of detectable transferrin.
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spelling pubmed-98072352023-01-09 Reversible atransferrinemia in a patient with chronic enteropathy: is transferrin mandatory for iron transport? Raynor, Alexandre Stefanescu, Carmen Bruneel, Arnaud Puy, Hervé Peoc’h, Katell Manceau, Hana Biochem Med (Zagreb) Case Report Herein, we report the case of a 42-year-old woman, hospitalized in a French tertiary hospital for a relapse of a chronic enteropathy, who was found on admission to have no detectable serum transferrin. Surprisingly, she only exhibited mild anaemia. This atransferrinemia persisted for two months throughout her hospitalization, during which her haemoglobin concentration remained broadly stable. Based on her clinical history and evolution, we concluded to an acquired atransferrinemia secondary to chronic undernutrition, inflammation and liver failure. We discuss the investigations performed in this patient, and hypotheses regarding the relative stability of her haemoglobin concentration despite the absence of detectable transferrin. Croatian Society of Medical Biochemistry and Laboratory Medicine 2022-12-15 2023-02-15 /pmc/articles/PMC9807235/ /pubmed/36627980 http://dx.doi.org/10.11613/BM.2023.010801 Text en Croatian Society of Medical Biochemistry and Laboratory Medicine. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Raynor, Alexandre
Stefanescu, Carmen
Bruneel, Arnaud
Puy, Hervé
Peoc’h, Katell
Manceau, Hana
Reversible atransferrinemia in a patient with chronic enteropathy: is transferrin mandatory for iron transport?
title Reversible atransferrinemia in a patient with chronic enteropathy: is transferrin mandatory for iron transport?
title_full Reversible atransferrinemia in a patient with chronic enteropathy: is transferrin mandatory for iron transport?
title_fullStr Reversible atransferrinemia in a patient with chronic enteropathy: is transferrin mandatory for iron transport?
title_full_unstemmed Reversible atransferrinemia in a patient with chronic enteropathy: is transferrin mandatory for iron transport?
title_short Reversible atransferrinemia in a patient with chronic enteropathy: is transferrin mandatory for iron transport?
title_sort reversible atransferrinemia in a patient with chronic enteropathy: is transferrin mandatory for iron transport?
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807235/
https://www.ncbi.nlm.nih.gov/pubmed/36627980
http://dx.doi.org/10.11613/BM.2023.010801
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