Cargando…

Malignant Apocrine Lesions of the Breast: Multimodality Imaging Findings and Biologic Features

The apocrine morphology of the breast is observed in a broad pathological spectrum, ranging from benign cysts to invasive carcinomas. However, the number of clinical research investigating malignant apocrine lesions is limited. This study retrospectively reviewed the data of patients with malignant...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Hyo-jae, Kang, Seung Wan, Lee, Jong Eun, Jeong, Won Gi, Lee, Ji Shin, Park, Min Ho, Lim, Hyo Soon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Breast Cancer Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807319/
https://www.ncbi.nlm.nih.gov/pubmed/36479602
http://dx.doi.org/10.4048/jbc.2022.25.e46
_version_ 1784862695554547712
author Lee, Hyo-jae
Kang, Seung Wan
Lee, Jong Eun
Jeong, Won Gi
Lee, Ji Shin
Park, Min Ho
Lim, Hyo Soon
author_facet Lee, Hyo-jae
Kang, Seung Wan
Lee, Jong Eun
Jeong, Won Gi
Lee, Ji Shin
Park, Min Ho
Lim, Hyo Soon
author_sort Lee, Hyo-jae
collection PubMed
description The apocrine morphology of the breast is observed in a broad pathological spectrum, ranging from benign cysts to invasive carcinomas. However, the number of clinical research investigating malignant apocrine lesions is limited. This study retrospectively reviewed the data of patients with malignant apocrine lesions admitted in a tertiary center between January 2004 and December 2021, based on the radiology-pathology correlation and the recent advances in their status to enhance the therapeutic implications of androgen receptor (AR). Among the 37 patients with lesions, 27 (73.0%) had triple-negative subtypes with predominant AR expression. The radiological features of malignant apocrine lesions did not differ from those of typical invasive ductal carcinoma or ductal carcinoma in situ. This study demonstrated that knowledge on the imaging features of malignant apocrine lesions and their histological basis could enhance the adoption of new targeted therapies in patients with this particular type of breast cancer.
format Online
Article
Text
id pubmed-9807319
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Korean Breast Cancer Society
record_format MEDLINE/PubMed
spelling pubmed-98073192023-01-10 Malignant Apocrine Lesions of the Breast: Multimodality Imaging Findings and Biologic Features Lee, Hyo-jae Kang, Seung Wan Lee, Jong Eun Jeong, Won Gi Lee, Ji Shin Park, Min Ho Lim, Hyo Soon J Breast Cancer Brief Communication The apocrine morphology of the breast is observed in a broad pathological spectrum, ranging from benign cysts to invasive carcinomas. However, the number of clinical research investigating malignant apocrine lesions is limited. This study retrospectively reviewed the data of patients with malignant apocrine lesions admitted in a tertiary center between January 2004 and December 2021, based on the radiology-pathology correlation and the recent advances in their status to enhance the therapeutic implications of androgen receptor (AR). Among the 37 patients with lesions, 27 (73.0%) had triple-negative subtypes with predominant AR expression. The radiological features of malignant apocrine lesions did not differ from those of typical invasive ductal carcinoma or ductal carcinoma in situ. This study demonstrated that knowledge on the imaging features of malignant apocrine lesions and their histological basis could enhance the adoption of new targeted therapies in patients with this particular type of breast cancer. Korean Breast Cancer Society 2022-11-14 /pmc/articles/PMC9807319/ /pubmed/36479602 http://dx.doi.org/10.4048/jbc.2022.25.e46 Text en © 2022 Korean Breast Cancer Society https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Lee, Hyo-jae
Kang, Seung Wan
Lee, Jong Eun
Jeong, Won Gi
Lee, Ji Shin
Park, Min Ho
Lim, Hyo Soon
Malignant Apocrine Lesions of the Breast: Multimodality Imaging Findings and Biologic Features
title Malignant Apocrine Lesions of the Breast: Multimodality Imaging Findings and Biologic Features
title_full Malignant Apocrine Lesions of the Breast: Multimodality Imaging Findings and Biologic Features
title_fullStr Malignant Apocrine Lesions of the Breast: Multimodality Imaging Findings and Biologic Features
title_full_unstemmed Malignant Apocrine Lesions of the Breast: Multimodality Imaging Findings and Biologic Features
title_short Malignant Apocrine Lesions of the Breast: Multimodality Imaging Findings and Biologic Features
title_sort malignant apocrine lesions of the breast: multimodality imaging findings and biologic features
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807319/
https://www.ncbi.nlm.nih.gov/pubmed/36479602
http://dx.doi.org/10.4048/jbc.2022.25.e46
work_keys_str_mv AT leehyojae malignantapocrinelesionsofthebreastmultimodalityimagingfindingsandbiologicfeatures
AT kangseungwan malignantapocrinelesionsofthebreastmultimodalityimagingfindingsandbiologicfeatures
AT leejongeun malignantapocrinelesionsofthebreastmultimodalityimagingfindingsandbiologicfeatures
AT jeongwongi malignantapocrinelesionsofthebreastmultimodalityimagingfindingsandbiologicfeatures
AT leejishin malignantapocrinelesionsofthebreastmultimodalityimagingfindingsandbiologicfeatures
AT parkminho malignantapocrinelesionsofthebreastmultimodalityimagingfindingsandbiologicfeatures
AT limhyosoon malignantapocrinelesionsofthebreastmultimodalityimagingfindingsandbiologicfeatures