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MICEmi: A method to identify cognitive endophenotypes of mental illnesses

BACKGROUND: Characterizing neurocognitive endophenotypes of mental illnesses (MIs) could be useful for identifying at-risk individuals, increasing early diagnosis, improving disease subtyping, and proposing therapeutic strategies to reduce the negative effects of the symptoms, in addition to serving...

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Detalles Bibliográficos
Autores principales: Correa-Ghisays, Patricia, Vicent Sánchez-Ortí, Joan, Balanzá-Martínez, Vicent, Fuentes-Durá, Inmaculada, Martinez-Aran, Anabel, Ruiz-Bolo, Lara, Correa-Estrada, Paulina, Ruiz-Ruiz, Juan Carlos, Selva-Vera, Gabriel, Vila-Francés, Joan, Macias Saint-Gerons, Diego, San-Martín, Constanza, Ayesa-Arriola, Rosa, Tabarés-Seisdedos, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807453/
https://www.ncbi.nlm.nih.gov/pubmed/36440538
http://dx.doi.org/10.1192/j.eurpsy.2022.2348
Descripción
Sumario:BACKGROUND: Characterizing neurocognitive endophenotypes of mental illnesses (MIs) could be useful for identifying at-risk individuals, increasing early diagnosis, improving disease subtyping, and proposing therapeutic strategies to reduce the negative effects of the symptoms, in addition to serving as a scientific basis to unravel the physiopathology of the disease. However, a standardized algorithm to determine cognitive endophenotypes has not yet been developed. The main objective of this study was to present a method for the identification of endophenotypes in MI research. METHODS: For this purpose, a 14-expert working group used a scoping review methodology and designed a method that includes a scoring template with five criteria and indicators, a strategy for their verification, and a decision tree. CONCLUSIONS: This work is ongoing since it is necessary to obtain external validation of the applicability of the method in future research.