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MICEmi: A method to identify cognitive endophenotypes of mental illnesses
BACKGROUND: Characterizing neurocognitive endophenotypes of mental illnesses (MIs) could be useful for identifying at-risk individuals, increasing early diagnosis, improving disease subtyping, and proposing therapeutic strategies to reduce the negative effects of the symptoms, in addition to serving...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807453/ https://www.ncbi.nlm.nih.gov/pubmed/36440538 http://dx.doi.org/10.1192/j.eurpsy.2022.2348 |
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author | Correa-Ghisays, Patricia Vicent Sánchez-Ortí, Joan Balanzá-Martínez, Vicent Fuentes-Durá, Inmaculada Martinez-Aran, Anabel Ruiz-Bolo, Lara Correa-Estrada, Paulina Ruiz-Ruiz, Juan Carlos Selva-Vera, Gabriel Vila-Francés, Joan Macias Saint-Gerons, Diego San-Martín, Constanza Ayesa-Arriola, Rosa Tabarés-Seisdedos, Rafael |
author_facet | Correa-Ghisays, Patricia Vicent Sánchez-Ortí, Joan Balanzá-Martínez, Vicent Fuentes-Durá, Inmaculada Martinez-Aran, Anabel Ruiz-Bolo, Lara Correa-Estrada, Paulina Ruiz-Ruiz, Juan Carlos Selva-Vera, Gabriel Vila-Francés, Joan Macias Saint-Gerons, Diego San-Martín, Constanza Ayesa-Arriola, Rosa Tabarés-Seisdedos, Rafael |
author_sort | Correa-Ghisays, Patricia |
collection | PubMed |
description | BACKGROUND: Characterizing neurocognitive endophenotypes of mental illnesses (MIs) could be useful for identifying at-risk individuals, increasing early diagnosis, improving disease subtyping, and proposing therapeutic strategies to reduce the negative effects of the symptoms, in addition to serving as a scientific basis to unravel the physiopathology of the disease. However, a standardized algorithm to determine cognitive endophenotypes has not yet been developed. The main objective of this study was to present a method for the identification of endophenotypes in MI research. METHODS: For this purpose, a 14-expert working group used a scoping review methodology and designed a method that includes a scoring template with five criteria and indicators, a strategy for their verification, and a decision tree. CONCLUSIONS: This work is ongoing since it is necessary to obtain external validation of the applicability of the method in future research. |
format | Online Article Text |
id | pubmed-9807453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-98074532023-01-04 MICEmi: A method to identify cognitive endophenotypes of mental illnesses Correa-Ghisays, Patricia Vicent Sánchez-Ortí, Joan Balanzá-Martínez, Vicent Fuentes-Durá, Inmaculada Martinez-Aran, Anabel Ruiz-Bolo, Lara Correa-Estrada, Paulina Ruiz-Ruiz, Juan Carlos Selva-Vera, Gabriel Vila-Francés, Joan Macias Saint-Gerons, Diego San-Martín, Constanza Ayesa-Arriola, Rosa Tabarés-Seisdedos, Rafael Eur Psychiatry Research Article BACKGROUND: Characterizing neurocognitive endophenotypes of mental illnesses (MIs) could be useful for identifying at-risk individuals, increasing early diagnosis, improving disease subtyping, and proposing therapeutic strategies to reduce the negative effects of the symptoms, in addition to serving as a scientific basis to unravel the physiopathology of the disease. However, a standardized algorithm to determine cognitive endophenotypes has not yet been developed. The main objective of this study was to present a method for the identification of endophenotypes in MI research. METHODS: For this purpose, a 14-expert working group used a scoping review methodology and designed a method that includes a scoring template with five criteria and indicators, a strategy for their verification, and a decision tree. CONCLUSIONS: This work is ongoing since it is necessary to obtain external validation of the applicability of the method in future research. Cambridge University Press 2022-11-28 /pmc/articles/PMC9807453/ /pubmed/36440538 http://dx.doi.org/10.1192/j.eurpsy.2022.2348 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike licence (http://creativecommons.org/licenses/by-nc-sa/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the same Creative Commons licence is used to distribute the re-used or adapted article and the original article is properly cited. The written permission of Cambridge University Press must be obtained prior to any commercial use. |
spellingShingle | Research Article Correa-Ghisays, Patricia Vicent Sánchez-Ortí, Joan Balanzá-Martínez, Vicent Fuentes-Durá, Inmaculada Martinez-Aran, Anabel Ruiz-Bolo, Lara Correa-Estrada, Paulina Ruiz-Ruiz, Juan Carlos Selva-Vera, Gabriel Vila-Francés, Joan Macias Saint-Gerons, Diego San-Martín, Constanza Ayesa-Arriola, Rosa Tabarés-Seisdedos, Rafael MICEmi: A method to identify cognitive endophenotypes of mental illnesses |
title | MICEmi: A method to identify cognitive endophenotypes of mental illnesses |
title_full | MICEmi: A method to identify cognitive endophenotypes of mental illnesses |
title_fullStr | MICEmi: A method to identify cognitive endophenotypes of mental illnesses |
title_full_unstemmed | MICEmi: A method to identify cognitive endophenotypes of mental illnesses |
title_short | MICEmi: A method to identify cognitive endophenotypes of mental illnesses |
title_sort | micemi: a method to identify cognitive endophenotypes of mental illnesses |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807453/ https://www.ncbi.nlm.nih.gov/pubmed/36440538 http://dx.doi.org/10.1192/j.eurpsy.2022.2348 |
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