Preclinical exploration of combined glucagon inhibition and liver-preferential insulin for treatment of diabetes using in vitro assays and rat and mouse models

AIMS/HYPOTHESIS: Normalisation of blood glucose in individuals with diabetes is recommended to reduce development of diabetic complications. However, risk of severe hypoglycaemia with intensive insulin therapy is a major obstacle that prevents many individuals with diabetes from obtaining the recomm...

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Detalles Bibliográficos
Autores principales: Hvid, Henning, Brand, Christian L., Hummelshøj, Tina, Jensen, Sanne, Bouman, Stephan D., Bowler, Andrew, Poulsen, Bjarne R., Tiainen, Peter, Åkertröm, Thorbjörn, Demozay, Damien, Hoeg-Jensen, Thomas, Ingvorsen, Camilla, Pedersen, Thomas Å., McGuire, Jim, Egebjerg, Thomas, Cappelen, Karen A., Eliasen, Ina P., Hansen, Bo F., Hennen, Stephanie, Stidsen, Carsten E., Olsen, Grith S., Roed, Nikolaj K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807490/
https://www.ncbi.nlm.nih.gov/pubmed/36404376
http://dx.doi.org/10.1007/s00125-022-05828-w

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