Novel hKDR mouse model depicts the antiangiogenesis and apoptosis‐promoting effects of neutralizing antibodies targeting vascular endothelial growth factor receptor 2

Vascular endothelial growth factor receptor 2 (VEGFR2)/KDR plays a critical role in tumor growth, diffusion, and invasion. The amino acid sequence homology of KDR between mouse and human in the VEGF ligand‐binding domain was low, thus the WT mice could not be used to evaluate Abs against human KDR,...

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Detalles Bibliográficos
Autores principales: Cao, Yuan, Sun, Chunyun, Huo, Guitao, Wang, Huiyu, Wu, Yong, Wang, Fei, Liu, Susu, Zhai, Shijie, Zhang, Xiao, Zhao, Haoyang, Hu, Meiling, Gu, Wenda, Yang, Yanwei, Wang, Sanlong, Liang, Chunnan, Lyu, Jianjun, Lu, Tiangong, Wang, Youchun, Xie, Liangzhi, Fan, Changfa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807522/
https://www.ncbi.nlm.nih.gov/pubmed/36114822
http://dx.doi.org/10.1111/cas.15594

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