Intra-islet insulin synthesis defects are associated with endoplasmic reticulum stress and loss of beta cell identity in human diabetes

AIMS/HYPOTHESIS: Endoplasmic reticulum (ER) stress and beta cell dedifferentiation both play leading roles in impaired insulin secretion in overt type 2 diabetes. Whether and how these factors are related in the natural history of the disease remains, however, unclear. METHODS: In this study, we ana...

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Detalles Bibliográficos
Autores principales: Brusco, Noemi, Sebastiani, Guido, Di Giuseppe, Gianfranco, Licata, Giada, Grieco, Giuseppina E., Fignani, Daniela, Nigi, Laura, Formichi, Caterina, Aiello, Elena, Auddino, Stefano, Quero, Giuseppe, Cefalo, Chiara M. A., Cinti, Francesca, Mari, Andrea, Ferraro, Pietro M., Pontecorvi, Alfredo, Alfieri, Sergio, Giaccari, Andrea, Dotta, Francesco, Mezza, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807540/
https://www.ncbi.nlm.nih.gov/pubmed/36280617
http://dx.doi.org/10.1007/s00125-022-05814-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807540/
https://www.ncbi.nlm.nih.gov/pubmed/36280617
http://dx.doi.org/10.1007/s00125-022-05814-2

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