Cargando…

Effects of Aficamten on cardiac contractility in a feline translational model of hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is the most prevalent inherited cardiac disease in humans and cats and lacks efficacious pharmacologic interventions in the preclinical phase of disease. LV outflow tract obstruction (LVOTO) is commonly observed in HCM-affected patients and is a primary driver of he...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sharpe, Ashley N., Oldach, Maureen S., Rivas, Victor N., Kaplan, Joanna L., Walker, Ashley L., Kovacs, Samantha L., Hwee, Darren T., Cremin, Peadar, Morgan, Bradley P., Malik, Fady I., Harris, Samantha P., Stern, Joshua A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807554/ https://www.ncbi.nlm.nih.gov/pubmed/36593243 http://dx.doi.org/10.1038/s41598-022-26630-z

Ejemplares similares

Pharmacokinetics of a single dose of Aficamten (CK‐274) on cardiac contractility in a A31P MYBPC3 hypertrophic cardiomyopathy cat model
por: Sharpe, Ashley N., et al.
Publicado: (2022)

Hypertrophic cardiomyopathy in purpose-bred cats with the A31P mutation in cardiac myosin binding protein-C
por: Stern, Joshua A., et al.
Publicado: (2023)

Cardiac Effects of a Single Dose of Pimobendan in Cats With Hypertrophic Cardiomyopathy; A Randomized, Placebo-Controlled, Crossover Study
por: Oldach, Maureen S., et al.
Publicado: (2019)

A Phase 1 Dose-Escalation Study of the Cardiac Myosin Inhibitor Aficamten in Healthy Participants
por: Malik, Fady I., et al.
Publicado: (2022)

A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy
por: Stern, Joshua A., et al.
Publicado: (2016)

Acute pharmacodynamic effects of pimobendan in client-owned cats with subclinical hypertrophic cardiomyopathy
por: Oldach, Maureen S., et al.
Publicado: (2021)

A genetic polymorphism in P2RY(1) impacts response to clopidogrel in cats with hypertrophic cardiomyopathy
por: Ueda, Yu, et al.
Publicado: (2021)

Multi-Omic, Histopathologic, and Clinicopathologic Effects of Once-Weekly Oral Rapamycin in a Naturally Occurring Feline Model of Hypertrophic Cardiomyopathy: A Pilot Study
por: Rivas, Victor N., et al.
Publicado: (2023)

Ambulatory electrocardiography, heart rate variability, and pharmacologic stress testing in cats with subclinical hypertrophic cardiomyopathy
por: Walker, Ashley L., et al.
Publicado: (2022)

The Feline Cardiomyopathies: 2. Hypertrophic cardiomyopathy
por: Kittleson, Mark D, et al.
Publicado: (2021)

Heritability and Pedigree Analyses of Hypertrophic Cardiomyopathy in Rhesus Macaques (Macaca Mulatta)
por: Ueda, Yu, et al.
Publicado: (2021)

Feline Hypertrophic Cardiomyopathy: A Spontaneous Large Animal Model of Human HCM
por: Freeman, Lisa M., et al.
Publicado: (2017)

Mechanistic complexity of contractile dysfunction in hypertrophic cardiomyopathy
por: Regnier, Michael
Publicado: (2018)

Synergistic inhibitory effects of clopidogrel and rivaroxaban on platelet function and platelet‐dependent thrombin generation in cats
por: Lo, Sara T., et al.
Publicado: (2023)

Assessment of dynamic cardiac repolarization and contractility in patients with hypertrophic cardiomyopathy
por: Radbill, Andrew E., et al.
Publicado: (2021)

Fibroblast Growth Factor Receptor 1 Signaling in Adult Cardiomyocytes Increases Contractility and Results in a Hypertrophic Cardiomyopathy
por: Cilvik, Sarah N., et al.
Publicado: (2013)

Deep learning-based diagnosis of feline hypertrophic cardiomyopathy
por: Rho, Jinhyung, et al.
Publicado: (2023)

Development of plasma and whole blood taurine reference ranges and identification of dietary features associated with taurine deficiency and dilated cardiomyopathy in golden retrievers: A prospective, observational study
por: Ontiveros, Eric S., et al.
Publicado: (2020)

Safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple doses of aficamten in healthy Chinese participants: a randomized, double-blind, placebo-controlled, phase 1 study
por: Zhao, Xue, et al.
Publicado: (2023)

Feline Interstitial Cystitis Enhances Mucosa-Dependent Contractile Responses to Serotonin
por: Ikeda, Youko, et al.
Publicado: (2018)

Stochastic allelic expression as trigger for contractile imbalance in hypertrophic cardiomyopathy
por: Montag, Judith, et al.
Publicado: (2020)

Exploration of Mediators Associated with Myocardial Remodelling in Feline Hypertrophic Cardiomyopathy
por: Cheng, Wan-Ching, et al.
Publicado: (2023)

Novel insights on the relationship between T-tubular defects and contractile dysfunction in a mouse model of hypertrophic cardiomyopathy
por: Crocini, C., et al.
Publicado: (2016)

Altered force generation and cell-to-cell contractile imbalance in hypertrophic cardiomyopathy
por: Kraft, Theresia, et al.
Publicado: (2019)

Hypertrophic Stimulation Increases β-actin Dynamics in Adult Feline Cardiomyocytes
por: Balasubramanian, Sundaravadivel, et al.
Publicado: (2010)

Myocarditis caused by Feline Immunodeficiency Virus in Five Cats with Hypertrophic Cardiomyopathy
por: Rolim, V. Machado, et al.
Publicado: (2016)

Effect of cellular and extracellular pathology assessed by T1 mapping on regional contractile function in hypertrophic cardiomyopathy
por: Swoboda, Peter P., et al.
Publicado: (2017)

Neuromuscular Junction Formation in Tissue-Engineered Skeletal Muscle Augments Contractile Function and Improves Cytoskeletal Organization
por: Martin, Neil R.W., et al.
Publicado: (2015)

Analysis of Contractile Function of Permeabilized Human Hypertrophic Cardiomyopathy Multicellular Heart Tissue
por: Kresin, Nico, et al.
Publicado: (2019)

Feline immunodeficiency virus latency
por: McDonnel, Samantha J, et al.
Publicado: (2013)

Acute echocardiographic effects of sotalol on ventricular systolic function in dogs with ventricular arrhythmias
por: Visser, Lance C., et al.
Publicado: (2018)

Circulating neutrophil extracellular traps in cats with hypertrophic cardiomyopathy and cardiogenic arterial thromboembolism
por: Li, Ronald H. L., et al.
Publicado: (2023)

Electrophysiological and Contractile Effects of Disopyramide in Patients With Obstructive Hypertrophic Cardiomyopathy: A Translational Study
por: Coppini, Raffaele, et al.
Publicado: (2019)

Feline hypertrophic cardiomyopathy: reduced microvascular density and involvement of CD34+ interstitial cells
por: Rodríguez, Josep M. Monné, et al.
Publicado: (2021)

Feline myocardial transcriptome in health and in hypertrophic cardiomyopathy—A translational animal model for human disease
por: Joshua, Jessica, et al.
Publicado: (2023)

Cardiomyocyte apoptosis contributes to contractile dysfunction in stem cell model of MYH7 E848G hypertrophic cardiomyopathy
por: Loiben, Alexander M., et al.
Publicado: (2023)

Cardiomyocyte Apoptosis Is Associated with Contractile Dysfunction in Stem Cell Model of MYH7 E848G Hypertrophic Cardiomyopathy
por: Loiben, Alexander M., et al.
Publicado: (2023)

Stable, Covalent Attachment of Laminin to Microposts Improves the Contractility of Mouse Neonatal Cardiomyocytes
por: Ribeiro, Alexandre J. S., et al.
Publicado: (2014)

Lipidomic Evaluation of Feline Neurologic Disease after AAV Gene Therapy
por: Gray-Edwards, Heather L., et al.
Publicado: (2017)

Subvalvular Aortic Stenosis: Learning From Human and Canine Clinical Research
por: Crofton, Amanda E., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_do8l9gd5cmkvvqdkhfkpjmirhk