Case report: Eosinophilic fasciitis induced by pembrolizumab with high FDG uptake on (18)F-FDG-PET/CT

Eosinophilic fasciitis (EF) is a rare connective tissue disorder causing inflammation and fibrosing of fascia. In this study, we present a very rare case of an immune checkpoint inhibitor (ICI)-induced EF revealed by (18)F-fluorodesoxyglucose positron emission tomography (FDG-PET/CT) 20 months after...

Descripción completa

Detalles Bibliográficos
Autores principales: Amrane, Karim, Le Meur, Coline, Thuillier, Philippe, Alemany, Pierre, Niel, Clémence, Renault, David, Abgral, Ronan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807755/
https://www.ncbi.nlm.nih.gov/pubmed/36606046
http://dx.doi.org/10.3389/fmed.2022.1078560
Descripción
Sumario:Eosinophilic fasciitis (EF) is a rare connective tissue disorder causing inflammation and fibrosing of fascia. In this study, we present a very rare case of an immune checkpoint inhibitor (ICI)-induced EF revealed by (18)F-fluorodesoxyglucose positron emission tomography (FDG-PET/CT) 20 months after the initiation of Pembrolizumab treatment of a relapsed non-small cell lung cancer (NSCLC). This study presents a 52-year-old Caucasian woman clinically presenting asthenia, inflammatory muscle, and joint pain associated with subcutaneous nodules and symmetrical edema of the lower limbs. Iterative (18)FDG-PET/CT scans allow us to guide the therapeutic strategy due to this atypical ICI adverse event.

Ejemplares similares