Case report: Eosinophilic fasciitis induced by pembrolizumab with high FDG uptake on (18)F-FDG-PET/CT

Eosinophilic fasciitis (EF) is a rare connective tissue disorder causing inflammation and fibrosing of fascia. In this study, we present a very rare case of an immune checkpoint inhibitor (ICI)-induced EF revealed by (18)F-fluorodesoxyglucose positron emission tomography (FDG-PET/CT) 20 months after...

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Autores principales: Amrane, Karim, Le Meur, Coline, Thuillier, Philippe, Alemany, Pierre, Niel, Clémence, Renault, David, Abgral, Ronan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807755/
https://www.ncbi.nlm.nih.gov/pubmed/36606046
http://dx.doi.org/10.3389/fmed.2022.1078560
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author Amrane, Karim
Le Meur, Coline
Thuillier, Philippe
Alemany, Pierre
Niel, Clémence
Renault, David
Abgral, Ronan
author_facet Amrane, Karim
Le Meur, Coline
Thuillier, Philippe
Alemany, Pierre
Niel, Clémence
Renault, David
Abgral, Ronan
author_sort Amrane, Karim
collection PubMed
description Eosinophilic fasciitis (EF) is a rare connective tissue disorder causing inflammation and fibrosing of fascia. In this study, we present a very rare case of an immune checkpoint inhibitor (ICI)-induced EF revealed by (18)F-fluorodesoxyglucose positron emission tomography (FDG-PET/CT) 20 months after the initiation of Pembrolizumab treatment of a relapsed non-small cell lung cancer (NSCLC). This study presents a 52-year-old Caucasian woman clinically presenting asthenia, inflammatory muscle, and joint pain associated with subcutaneous nodules and symmetrical edema of the lower limbs. Iterative (18)FDG-PET/CT scans allow us to guide the therapeutic strategy due to this atypical ICI adverse event.
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spelling pubmed-98077552023-01-04 Case report: Eosinophilic fasciitis induced by pembrolizumab with high FDG uptake on (18)F-FDG-PET/CT Amrane, Karim Le Meur, Coline Thuillier, Philippe Alemany, Pierre Niel, Clémence Renault, David Abgral, Ronan Front Med (Lausanne) Medicine Eosinophilic fasciitis (EF) is a rare connective tissue disorder causing inflammation and fibrosing of fascia. In this study, we present a very rare case of an immune checkpoint inhibitor (ICI)-induced EF revealed by (18)F-fluorodesoxyglucose positron emission tomography (FDG-PET/CT) 20 months after the initiation of Pembrolizumab treatment of a relapsed non-small cell lung cancer (NSCLC). This study presents a 52-year-old Caucasian woman clinically presenting asthenia, inflammatory muscle, and joint pain associated with subcutaneous nodules and symmetrical edema of the lower limbs. Iterative (18)FDG-PET/CT scans allow us to guide the therapeutic strategy due to this atypical ICI adverse event. Frontiers Media S.A. 2022-12-20 /pmc/articles/PMC9807755/ /pubmed/36606046 http://dx.doi.org/10.3389/fmed.2022.1078560 Text en Copyright © 2022 Amrane, Le Meur, Thuillier, Alemany, Niel, Renault and Abgral. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Amrane, Karim
Le Meur, Coline
Thuillier, Philippe
Alemany, Pierre
Niel, Clémence
Renault, David
Abgral, Ronan
Case report: Eosinophilic fasciitis induced by pembrolizumab with high FDG uptake on (18)F-FDG-PET/CT
title Case report: Eosinophilic fasciitis induced by pembrolizumab with high FDG uptake on (18)F-FDG-PET/CT
title_full Case report: Eosinophilic fasciitis induced by pembrolizumab with high FDG uptake on (18)F-FDG-PET/CT
title_fullStr Case report: Eosinophilic fasciitis induced by pembrolizumab with high FDG uptake on (18)F-FDG-PET/CT
title_full_unstemmed Case report: Eosinophilic fasciitis induced by pembrolizumab with high FDG uptake on (18)F-FDG-PET/CT
title_short Case report: Eosinophilic fasciitis induced by pembrolizumab with high FDG uptake on (18)F-FDG-PET/CT
title_sort case report: eosinophilic fasciitis induced by pembrolizumab with high fdg uptake on (18)f-fdg-pet/ct
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807755/
https://www.ncbi.nlm.nih.gov/pubmed/36606046
http://dx.doi.org/10.3389/fmed.2022.1078560
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