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The HLA class-II immunopeptidomes of AAV capsids proteins

INTRODUCTION: Gene therapies are using Adeno-associated viruses (AAVs) as vectors, but immune responses against the capsids pose challenges to their efficiency and safety. Helper T cell recognition of capsid-derived peptides bound to human leukocyte antigen (HLA) class II molecules is an essential s...

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Detalles Bibliográficos
Autores principales:	Brito-Sierra, Carlos A., Lannan, Megan B., Siegel, Robert W., Malherbe, Laurent P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807805/ https://www.ncbi.nlm.nih.gov/pubmed/36605211 http://dx.doi.org/10.3389/fimmu.2022.1067399

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