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Advances in bone regeneration with growth factors for spinal fusion: A literature review

Bone tissue is regenerated via the spatiotemporal involvement of various cytokines. Among them, the bone morphogenetic protein (BMP), which plays a vital role in the bone regeneration process, has been applied clinically for the treatment of refractory orthopedic conditions. Although BMP therapy usi...

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Detalles Bibliográficos
Autores principales: Tateiwa, Daisuke, Kaito, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807829/
https://www.ncbi.nlm.nih.gov/pubmed/36605107
http://dx.doi.org/10.1016/j.xnsj.2022.100193
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author Tateiwa, Daisuke
Kaito, Takashi
author_facet Tateiwa, Daisuke
Kaito, Takashi
author_sort Tateiwa, Daisuke
collection PubMed
description Bone tissue is regenerated via the spatiotemporal involvement of various cytokines. Among them, the bone morphogenetic protein (BMP), which plays a vital role in the bone regeneration process, has been applied clinically for the treatment of refractory orthopedic conditions. Although BMP therapy using a collagen carrier has shown efficiency in bone regeneration over the last two decades, a major challenge—considerable side effects associated with the acute release of high doses of BMPs—has also been revealed. To improve BMP efficiency, the development of new carriers and biologics that can be used in conjunction with BMPs is currently underway. In this review, we describe the current status and future prospects of bone regeneration therapy, with a focus on BMPs. Furthermore, we outline the characteristics and molecular signaling pathways involving BMPs, clinical applications of BMPs in orthopedics, clinical results of BMP use in human spinal surgeries, drugs combined with BMPs to provide synergistic effects, and novel BMP carriers.
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spelling pubmed-98078292023-01-04 Advances in bone regeneration with growth factors for spinal fusion: A literature review Tateiwa, Daisuke Kaito, Takashi N Am Spine Soc J Advances in Spinal Regenerative Therapies Bone tissue is regenerated via the spatiotemporal involvement of various cytokines. Among them, the bone morphogenetic protein (BMP), which plays a vital role in the bone regeneration process, has been applied clinically for the treatment of refractory orthopedic conditions. Although BMP therapy using a collagen carrier has shown efficiency in bone regeneration over the last two decades, a major challenge—considerable side effects associated with the acute release of high doses of BMPs—has also been revealed. To improve BMP efficiency, the development of new carriers and biologics that can be used in conjunction with BMPs is currently underway. In this review, we describe the current status and future prospects of bone regeneration therapy, with a focus on BMPs. Furthermore, we outline the characteristics and molecular signaling pathways involving BMPs, clinical applications of BMPs in orthopedics, clinical results of BMP use in human spinal surgeries, drugs combined with BMPs to provide synergistic effects, and novel BMP carriers. Elsevier 2022-12-17 /pmc/articles/PMC9807829/ /pubmed/36605107 http://dx.doi.org/10.1016/j.xnsj.2022.100193 Text en © 2022 The Author(s). Published by Elsevier Ltd on behalf of North American Spine Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Advances in Spinal Regenerative Therapies
Tateiwa, Daisuke
Kaito, Takashi
Advances in bone regeneration with growth factors for spinal fusion: A literature review
title Advances in bone regeneration with growth factors for spinal fusion: A literature review
title_full Advances in bone regeneration with growth factors for spinal fusion: A literature review
title_fullStr Advances in bone regeneration with growth factors for spinal fusion: A literature review
title_full_unstemmed Advances in bone regeneration with growth factors for spinal fusion: A literature review
title_short Advances in bone regeneration with growth factors for spinal fusion: A literature review
title_sort advances in bone regeneration with growth factors for spinal fusion: a literature review
topic Advances in Spinal Regenerative Therapies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807829/
https://www.ncbi.nlm.nih.gov/pubmed/36605107
http://dx.doi.org/10.1016/j.xnsj.2022.100193
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