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COVID-19 Vaccine During Pregnancy and Perinatal Outcomes

Introduction When COVID-19 vaccination started, there was little data on the safety of immunization against COVID-19 infection in pregnant women. Previous studies revealed no safety concerns for pregnant women or newborns who received a messenger ribonucleic acid (mRNA) COVID-19 vaccine during pregn...

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Autores principales: Almutairi, Amani, Asiri, Mufareh, Alsuwaidan, Salem, Sufyani, Reem, AlSalem, Shumukh, Alghamdi, Joud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807835/
https://www.ncbi.nlm.nih.gov/pubmed/36606110
http://dx.doi.org/10.7759/cureus.33240
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author Almutairi, Amani
Asiri, Mufareh
Alsuwaidan, Salem
Sufyani, Reem
AlSalem, Shumukh
Alghamdi, Joud
author_facet Almutairi, Amani
Asiri, Mufareh
Alsuwaidan, Salem
Sufyani, Reem
AlSalem, Shumukh
Alghamdi, Joud
author_sort Almutairi, Amani
collection PubMed
description Introduction When COVID-19 vaccination started, there was little data on the safety of immunization against COVID-19 infection in pregnant women. Previous studies revealed no safety concerns for pregnant women or newborns who received a messenger ribonucleic acid (mRNA) COVID-19 vaccine during pregnancy. This study aimed to investigate the effects of COVID-19 vaccination on pregnant women and on perinatal outcomes. Methods This cross-sectional study was conducted in a maternity hospital in King Saud Medical City. It started in January 2022 and ended in June 2022. The questionnaire was developed and validated by experts. This study included all women admitted to the postpartum ward who were more than 18 years old and had received the COVID-19 vaccine. The study excluded women who had no proof of their vaccination status or who could not complete the questionnaire. The primary outcome was the effect of COVID-19 vaccination on gestational age and birth weight. The secondary outcomes included the development of polyhydramnios, oligohydramnios, mode of delivery, Apgar score, postpartum hemorrhage, and neonatal intensive care unit admission. Results A total of 365 pregnant women participated in this study. The mean gestational age of the unvaccinated women was 38.83 ± 1.62 weeks, which was significantly (p < 0.001) higher than that of vaccinated women (37.69 ± 2.9 weeks). In addition, the average birth weight for the unvaccinated women was 2.96 ± 0.4 kg, which did not differ significantly (p = 0.89) from that of vaccinated women (2.97 ± 0.66 kg). Conclusion COVID-19 vaccination, regardless of the type of vaccine received before, during, or after pregnancy, is not associated with any unfavorable perinatal outcomes for pregnant women or neonates.
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spelling pubmed-98078352023-01-04 COVID-19 Vaccine During Pregnancy and Perinatal Outcomes Almutairi, Amani Asiri, Mufareh Alsuwaidan, Salem Sufyani, Reem AlSalem, Shumukh Alghamdi, Joud Cureus Obstetrics/Gynecology Introduction When COVID-19 vaccination started, there was little data on the safety of immunization against COVID-19 infection in pregnant women. Previous studies revealed no safety concerns for pregnant women or newborns who received a messenger ribonucleic acid (mRNA) COVID-19 vaccine during pregnancy. This study aimed to investigate the effects of COVID-19 vaccination on pregnant women and on perinatal outcomes. Methods This cross-sectional study was conducted in a maternity hospital in King Saud Medical City. It started in January 2022 and ended in June 2022. The questionnaire was developed and validated by experts. This study included all women admitted to the postpartum ward who were more than 18 years old and had received the COVID-19 vaccine. The study excluded women who had no proof of their vaccination status or who could not complete the questionnaire. The primary outcome was the effect of COVID-19 vaccination on gestational age and birth weight. The secondary outcomes included the development of polyhydramnios, oligohydramnios, mode of delivery, Apgar score, postpartum hemorrhage, and neonatal intensive care unit admission. Results A total of 365 pregnant women participated in this study. The mean gestational age of the unvaccinated women was 38.83 ± 1.62 weeks, which was significantly (p < 0.001) higher than that of vaccinated women (37.69 ± 2.9 weeks). In addition, the average birth weight for the unvaccinated women was 2.96 ± 0.4 kg, which did not differ significantly (p = 0.89) from that of vaccinated women (2.97 ± 0.66 kg). Conclusion COVID-19 vaccination, regardless of the type of vaccine received before, during, or after pregnancy, is not associated with any unfavorable perinatal outcomes for pregnant women or neonates. Cureus 2023-01-02 /pmc/articles/PMC9807835/ /pubmed/36606110 http://dx.doi.org/10.7759/cureus.33240 Text en Copyright © 2023, Almutairi et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Obstetrics/Gynecology
Almutairi, Amani
Asiri, Mufareh
Alsuwaidan, Salem
Sufyani, Reem
AlSalem, Shumukh
Alghamdi, Joud
COVID-19 Vaccine During Pregnancy and Perinatal Outcomes
title COVID-19 Vaccine During Pregnancy and Perinatal Outcomes
title_full COVID-19 Vaccine During Pregnancy and Perinatal Outcomes
title_fullStr COVID-19 Vaccine During Pregnancy and Perinatal Outcomes
title_full_unstemmed COVID-19 Vaccine During Pregnancy and Perinatal Outcomes
title_short COVID-19 Vaccine During Pregnancy and Perinatal Outcomes
title_sort covid-19 vaccine during pregnancy and perinatal outcomes
topic Obstetrics/Gynecology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807835/
https://www.ncbi.nlm.nih.gov/pubmed/36606110
http://dx.doi.org/10.7759/cureus.33240
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