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Mitochondrial dysfunction in vascular endothelial cells and its role in atherosclerosis
The mitochondria are essential organelles that generate large amounts of ATP via the electron transport chain (ECT). Mitochondrial dysfunction causes reactive oxygen species accumulation, energy stress, and cell death. Endothelial mitochondrial dysfunction is an important factor causing abnormal fun...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807884/ https://www.ncbi.nlm.nih.gov/pubmed/36605901 http://dx.doi.org/10.3389/fphys.2022.1084604 |
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author | Qu, Kai Yan, Fang Qin, Xian Zhang, Kun He, Wen Dong, Mingqing Wu, Guicheng |
author_facet | Qu, Kai Yan, Fang Qin, Xian Zhang, Kun He, Wen Dong, Mingqing Wu, Guicheng |
author_sort | Qu, Kai |
collection | PubMed |
description | The mitochondria are essential organelles that generate large amounts of ATP via the electron transport chain (ECT). Mitochondrial dysfunction causes reactive oxygen species accumulation, energy stress, and cell death. Endothelial mitochondrial dysfunction is an important factor causing abnormal function of the endothelium, which plays a central role during atherosclerosis development. Atherosclerosis-related risk factors, including high glucose levels, hypertension, ischemia, hypoxia, and diabetes, promote mitochondrial dysfunction in endothelial cells. This review summarizes the physiological and pathophysiological roles of endothelial mitochondria in endothelial function and atherosclerosis. |
format | Online Article Text |
id | pubmed-9807884 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98078842023-01-04 Mitochondrial dysfunction in vascular endothelial cells and its role in atherosclerosis Qu, Kai Yan, Fang Qin, Xian Zhang, Kun He, Wen Dong, Mingqing Wu, Guicheng Front Physiol Physiology The mitochondria are essential organelles that generate large amounts of ATP via the electron transport chain (ECT). Mitochondrial dysfunction causes reactive oxygen species accumulation, energy stress, and cell death. Endothelial mitochondrial dysfunction is an important factor causing abnormal function of the endothelium, which plays a central role during atherosclerosis development. Atherosclerosis-related risk factors, including high glucose levels, hypertension, ischemia, hypoxia, and diabetes, promote mitochondrial dysfunction in endothelial cells. This review summarizes the physiological and pathophysiological roles of endothelial mitochondria in endothelial function and atherosclerosis. Frontiers Media S.A. 2022-12-20 /pmc/articles/PMC9807884/ /pubmed/36605901 http://dx.doi.org/10.3389/fphys.2022.1084604 Text en Copyright © 2022 Qu, Yan, Qin, Zhang, He, Dong and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Qu, Kai Yan, Fang Qin, Xian Zhang, Kun He, Wen Dong, Mingqing Wu, Guicheng Mitochondrial dysfunction in vascular endothelial cells and its role in atherosclerosis |
title | Mitochondrial dysfunction in vascular endothelial cells and its role in atherosclerosis |
title_full | Mitochondrial dysfunction in vascular endothelial cells and its role in atherosclerosis |
title_fullStr | Mitochondrial dysfunction in vascular endothelial cells and its role in atherosclerosis |
title_full_unstemmed | Mitochondrial dysfunction in vascular endothelial cells and its role in atherosclerosis |
title_short | Mitochondrial dysfunction in vascular endothelial cells and its role in atherosclerosis |
title_sort | mitochondrial dysfunction in vascular endothelial cells and its role in atherosclerosis |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807884/ https://www.ncbi.nlm.nih.gov/pubmed/36605901 http://dx.doi.org/10.3389/fphys.2022.1084604 |
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