Comparison of subcutaneous inflammatory response induced by elastomeric orthodontic ligatures coated with silver and zinc oxide nanoparticles with control group on rats

BACKGROUND: Silver and zinc oxide (ZnO) nanoparticles have recently become common to coat ligatures in order to take advantage of positive properties of nanoparticles, although there are concerns about their cytotoxicity. This study tended to compare subcutaneous inflammatory response induced by ela...

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Autores principales: Sadeghian, Soosan, Ersi, Mahnaz, Kalbasi, Nader, Najjarian, Mojtaba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807938/
https://www.ncbi.nlm.nih.gov/pubmed/36605142
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author Sadeghian, Soosan
Ersi, Mahnaz
Kalbasi, Nader
Najjarian, Mojtaba
author_facet Sadeghian, Soosan
Ersi, Mahnaz
Kalbasi, Nader
Najjarian, Mojtaba
author_sort Sadeghian, Soosan
collection PubMed
description BACKGROUND: Silver and zinc oxide (ZnO) nanoparticles have recently become common to coat ligatures in order to take advantage of positive properties of nanoparticles, although there are concerns about their cytotoxicity. This study tended to compare subcutaneous inflammatory response induced by elastomeric orthodontic ligatures coated with silver and ZnO nanoparticles with a control group in rats. MATERIALS AND METHODS: In this in vitro and animal cross-sectional descriptive-analytical study, silver nanoparticles were synthesized by chemical reduction of silver nitrate solution in the presence of sodium borohydride and ZnO nanoparticles by the same method and by chemical reduction of zinc sulfate solution with sodium hydroxide and were coated on elastomeric ligatures. Subcutaneous inflammation degrees were assessed after 15 and 30 days and were compared in the groups by Kruskal–Wallis test and ordinal generalized estimation equation with exchangeable correlation matrix. All tests were performed with a significance level (P = 0.05). RESULTS: There was a significant difference in terms of degrees of inflammation in the groups coated with ZnO nanoparticles (P = 0.003) and silver nanoparticles (P = 0.04) compared to the control group in 15- and 30-day samples. Zinc nanoparticles caused 3.22 times more inflammation than silver nanoparticles (P = 0.053). The decrease in inflammation was significant over time in all groups (P = 0.001). CONCLUSION: There was a significant more inflammation in the groups receiving ZnO and silver nanoparticles compared to the control group in 15- and 30-day samples. Silver nanoparticles are probably safer than zinc nanoparticles for tissue and a better material to choose for antibacterial effects.
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spelling pubmed-98079382023-01-04 Comparison of subcutaneous inflammatory response induced by elastomeric orthodontic ligatures coated with silver and zinc oxide nanoparticles with control group on rats Sadeghian, Soosan Ersi, Mahnaz Kalbasi, Nader Najjarian, Mojtaba Dent Res J (Isfahan) Original Article BACKGROUND: Silver and zinc oxide (ZnO) nanoparticles have recently become common to coat ligatures in order to take advantage of positive properties of nanoparticles, although there are concerns about their cytotoxicity. This study tended to compare subcutaneous inflammatory response induced by elastomeric orthodontic ligatures coated with silver and ZnO nanoparticles with a control group in rats. MATERIALS AND METHODS: In this in vitro and animal cross-sectional descriptive-analytical study, silver nanoparticles were synthesized by chemical reduction of silver nitrate solution in the presence of sodium borohydride and ZnO nanoparticles by the same method and by chemical reduction of zinc sulfate solution with sodium hydroxide and were coated on elastomeric ligatures. Subcutaneous inflammation degrees were assessed after 15 and 30 days and were compared in the groups by Kruskal–Wallis test and ordinal generalized estimation equation with exchangeable correlation matrix. All tests were performed with a significance level (P = 0.05). RESULTS: There was a significant difference in terms of degrees of inflammation in the groups coated with ZnO nanoparticles (P = 0.003) and silver nanoparticles (P = 0.04) compared to the control group in 15- and 30-day samples. Zinc nanoparticles caused 3.22 times more inflammation than silver nanoparticles (P = 0.053). The decrease in inflammation was significant over time in all groups (P = 0.001). CONCLUSION: There was a significant more inflammation in the groups receiving ZnO and silver nanoparticles compared to the control group in 15- and 30-day samples. Silver nanoparticles are probably safer than zinc nanoparticles for tissue and a better material to choose for antibacterial effects. Wolters Kluwer - Medknow 2022-11-17 /pmc/articles/PMC9807938/ /pubmed/36605142 Text en Copyright: © 2022 Dental Research Journal https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Sadeghian, Soosan
Ersi, Mahnaz
Kalbasi, Nader
Najjarian, Mojtaba
Comparison of subcutaneous inflammatory response induced by elastomeric orthodontic ligatures coated with silver and zinc oxide nanoparticles with control group on rats
title Comparison of subcutaneous inflammatory response induced by elastomeric orthodontic ligatures coated with silver and zinc oxide nanoparticles with control group on rats
title_full Comparison of subcutaneous inflammatory response induced by elastomeric orthodontic ligatures coated with silver and zinc oxide nanoparticles with control group on rats
title_fullStr Comparison of subcutaneous inflammatory response induced by elastomeric orthodontic ligatures coated with silver and zinc oxide nanoparticles with control group on rats
title_full_unstemmed Comparison of subcutaneous inflammatory response induced by elastomeric orthodontic ligatures coated with silver and zinc oxide nanoparticles with control group on rats
title_short Comparison of subcutaneous inflammatory response induced by elastomeric orthodontic ligatures coated with silver and zinc oxide nanoparticles with control group on rats
title_sort comparison of subcutaneous inflammatory response induced by elastomeric orthodontic ligatures coated with silver and zinc oxide nanoparticles with control group on rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807938/
https://www.ncbi.nlm.nih.gov/pubmed/36605142
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