Next-generation retinoid X receptor agonists increase ATRA signaling in organotypic epithelium cultures and have distinct effects on receptor dynamics

Retinoid X receptors (RXRs) are nuclear transcription factors that partner with other nuclear receptors to regulate numerous physiological processes. Although RXR represents a valid therapeutic target, only a few RXR-specific ligands (rexinoids) have been identified, in part due to the lack of clari...

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Detalles Bibliográficos
Autores principales: Melo, Nathalia, Belyaeva, Olga V., Berger, Wilhelm K., Halasz, Laszlo, Yu, Jianshi, Pilli, Nagesh, Yang, Zhengrong, Klyuyeva, Alla V., Elmets, Craig A., Atigadda, Venkatram, Muccio, Donald D., Kane, Maureen A., Nagy, Laszlo, Kedishvili, Natalia Y., Renfrow, Matthew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807999/
https://www.ncbi.nlm.nih.gov/pubmed/36436565
http://dx.doi.org/10.1016/j.jbc.2022.102746

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