A midposition NOTCH3 truncation in inherited cerebral small vessel disease may affect the protein interactome

Mutations in NOTCH3 underlie cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the most common inherited cerebral small vessel disease. Two cleavages of NOTCH3 protein, at Asp80 and Asp121, were previously described in CADASIL pathological samples....

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Detalles Bibliográficos
Autores principales: Lee, Soo Jung, Zhang, Xiaojie, Xu, Gang, Borjigin, Jimo, Wang, Michael M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808000/
https://www.ncbi.nlm.nih.gov/pubmed/36470429
http://dx.doi.org/10.1016/j.jbc.2022.102772

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