Mapping the KRAS proteoform landscape in colorectal cancer identifies truncated KRAS4B that decreases MAPK signaling

The KRAS gene is one of the most frequently mutated oncogenes in human cancer and gives rise to two isoforms, KRAS4A and KRAS4B. KRAS post-translational modifications (PTMs) have the potential to influence downstream signaling. However, the relationship between KRAS PTMs and oncogenic mutations rema...

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Detalles Bibliográficos
Autores principales: Adams, Lauren M., DeHart, Caroline J., Drown, Bryon S., Anderson, Lissa C., Bocik, William, Boja, Emily S., Hiltke, Tara M., Hendrickson, Christopher L., Rodriguez, Henry, Caldwell, Michael, Vafabakhsh, Reza, Kelleher, Neil L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808003/
https://www.ncbi.nlm.nih.gov/pubmed/36470426
http://dx.doi.org/10.1016/j.jbc.2022.102768

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