Efficient and error-free correction of sickle mutation in human erythroid cells using prime editor-2

Sickle cell anaemia (SCA) is one of the common autosomal recessive monogenic disorders, caused by a transverse point mutation (GAG > GTG) at the sixth codon of the beta-globin gene, which results in haemolytic anaemia due to the fragile RBCs. Recent progress in genome editing has gained attention...

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Detalles Bibliográficos
Autores principales: George, Anila, Ravi, Nithin Sam, Prasad, Kirti, Panigrahi, Lokesh, Koikkara, Sanya, Rajendiran, Vignesh, Devaraju, Nivedhitha, Paul, Joshua, Pai, Aswin Anand, Nakamura, Yukio, Kurita, Ryo, Balasubramanian, Poonkuzhali, Thangavel, Saravanabhavan, Marepally, Srujan, Velayudhan, Shaji R., Srivastava, Alok, Mohankumar, Kumarasamypet M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genome Editing
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808041/
https://www.ncbi.nlm.nih.gov/pubmed/36605051
http://dx.doi.org/10.3389/fgeed.2022.1085111

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