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Advances and perspectives on perylenequinone biosynthesis

Under illumination, the fungal secondary metabolites, perylenequinones (PQs) react with molecular oxygen to generate reactive oxygen species (ROS), which, in excess can damage cellular macromolecules and trigger apoptosis. Based on this property, PQs have been widely used as photosensitizers and app...

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Autores principales: Deng, Huaxiang, Liang, Xinxin, Liu, Jinbin, Zheng, Xiaohui, Fan, Tai-Ping, Cai, Yujie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808054/
https://www.ncbi.nlm.nih.gov/pubmed/36605511
http://dx.doi.org/10.3389/fmicb.2022.1070110
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author Deng, Huaxiang
Liang, Xinxin
Liu, Jinbin
Zheng, Xiaohui
Fan, Tai-Ping
Cai, Yujie
author_facet Deng, Huaxiang
Liang, Xinxin
Liu, Jinbin
Zheng, Xiaohui
Fan, Tai-Ping
Cai, Yujie
author_sort Deng, Huaxiang
collection PubMed
description Under illumination, the fungal secondary metabolites, perylenequinones (PQs) react with molecular oxygen to generate reactive oxygen species (ROS), which, in excess can damage cellular macromolecules and trigger apoptosis. Based on this property, PQs have been widely used as photosensitizers and applied in pharmaceuticals, which has stimulated research into the discovery of new PQs and the elucidation of their biosynthetic pathways. The PQs-associated literature covering from April 1967 to September 2022 is reviewed in three sections: (1) the sources, structural diversity, and biological activities of microbial PQs; (2) elucidation of PQ biosynthetic pathways, associated genes, and mechanisms of regulation; and (3) advances in pathway engineering and future potential strategies to modify cellular metabolism and improve PQ production.
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spelling pubmed-98080542023-01-04 Advances and perspectives on perylenequinone biosynthesis Deng, Huaxiang Liang, Xinxin Liu, Jinbin Zheng, Xiaohui Fan, Tai-Ping Cai, Yujie Front Microbiol Microbiology Under illumination, the fungal secondary metabolites, perylenequinones (PQs) react with molecular oxygen to generate reactive oxygen species (ROS), which, in excess can damage cellular macromolecules and trigger apoptosis. Based on this property, PQs have been widely used as photosensitizers and applied in pharmaceuticals, which has stimulated research into the discovery of new PQs and the elucidation of their biosynthetic pathways. The PQs-associated literature covering from April 1967 to September 2022 is reviewed in three sections: (1) the sources, structural diversity, and biological activities of microbial PQs; (2) elucidation of PQ biosynthetic pathways, associated genes, and mechanisms of regulation; and (3) advances in pathway engineering and future potential strategies to modify cellular metabolism and improve PQ production. Frontiers Media S.A. 2022-12-20 /pmc/articles/PMC9808054/ /pubmed/36605511 http://dx.doi.org/10.3389/fmicb.2022.1070110 Text en Copyright © 2022 Deng, Liang, Liu, Zheng, Fan and Cai. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Deng, Huaxiang
Liang, Xinxin
Liu, Jinbin
Zheng, Xiaohui
Fan, Tai-Ping
Cai, Yujie
Advances and perspectives on perylenequinone biosynthesis
title Advances and perspectives on perylenequinone biosynthesis
title_full Advances and perspectives on perylenequinone biosynthesis
title_fullStr Advances and perspectives on perylenequinone biosynthesis
title_full_unstemmed Advances and perspectives on perylenequinone biosynthesis
title_short Advances and perspectives on perylenequinone biosynthesis
title_sort advances and perspectives on perylenequinone biosynthesis
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808054/
https://www.ncbi.nlm.nih.gov/pubmed/36605511
http://dx.doi.org/10.3389/fmicb.2022.1070110
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