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How toxic is the COVID-19 drug azithromycin in the presence of Posidonia oceanica? Toxicokinetics and experimental approach of meiobenthic nematodes from a metallically pristine area()
The current study presents the results of an experiment carried to assess the impact of azithromycin, a COVID-19 drug, probably accumulated in marine sediments for three years, since the start of the pandemic, on benthic marine nematodes. It was explored the extent to which a common macrophyte from...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808061/ https://www.ncbi.nlm.nih.gov/pubmed/36608722 http://dx.doi.org/10.1016/j.envpol.2023.121007 |
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author | Badraoui, Riadh Mannai, Ghofrane Siddiqui, Arif J. Pacioglu, Octavian Rudayni, Hassan A. Boufahja, Fehmi Essid, Naceur |
author_facet | Badraoui, Riadh Mannai, Ghofrane Siddiqui, Arif J. Pacioglu, Octavian Rudayni, Hassan A. Boufahja, Fehmi Essid, Naceur |
author_sort | Badraoui, Riadh |
collection | PubMed |
description | The current study presents the results of an experiment carried to assess the impact of azithromycin, a COVID-19 drug, probably accumulated in marine sediments for three years, since the start of the pandemic, on benthic marine nematodes. It was explored the extent to which a common macrophyte from the Mediterranean Sea influenced the toxic impact of azithromycin on meiobenthic nematodes. Metals are known to influence toxicity of azithromycin. The nematofauna from a metallically pristine site situated in Bizerte bay, Tunisia, was exposed to two concentrations of azithromycin [i.e. 5 and 10 μg l(−1)]. In addition, two masses of the common macrophyte Posidonia oceanica [10 and 20% Dry Weight (DW)] were considered and associated with azithromycin into four possible combinations. The abundance and the taxonomic diversity of the nematode communities decreased significantly following the exposure to azithromycin, which was confirmed by the toxicokinetic data and behaving as substrate for P-glycoprotein (P-gp). The toxicity of 5 μg l(−1) dosage of azithromycin was partially reduced at 10% DW of Posidonia and completely at 20% DW. The results showed that 5 μg l(−1) of azithromycin can be reduced by the macrophyte P. oceanica when present in the environment at low masses as 10% DW. |
format | Online Article Text |
id | pubmed-9808061 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98080612023-01-04 How toxic is the COVID-19 drug azithromycin in the presence of Posidonia oceanica? Toxicokinetics and experimental approach of meiobenthic nematodes from a metallically pristine area() Badraoui, Riadh Mannai, Ghofrane Siddiqui, Arif J. Pacioglu, Octavian Rudayni, Hassan A. Boufahja, Fehmi Essid, Naceur Environ Pollut Article The current study presents the results of an experiment carried to assess the impact of azithromycin, a COVID-19 drug, probably accumulated in marine sediments for three years, since the start of the pandemic, on benthic marine nematodes. It was explored the extent to which a common macrophyte from the Mediterranean Sea influenced the toxic impact of azithromycin on meiobenthic nematodes. Metals are known to influence toxicity of azithromycin. The nematofauna from a metallically pristine site situated in Bizerte bay, Tunisia, was exposed to two concentrations of azithromycin [i.e. 5 and 10 μg l(−1)]. In addition, two masses of the common macrophyte Posidonia oceanica [10 and 20% Dry Weight (DW)] were considered and associated with azithromycin into four possible combinations. The abundance and the taxonomic diversity of the nematode communities decreased significantly following the exposure to azithromycin, which was confirmed by the toxicokinetic data and behaving as substrate for P-glycoprotein (P-gp). The toxicity of 5 μg l(−1) dosage of azithromycin was partially reduced at 10% DW of Posidonia and completely at 20% DW. The results showed that 5 μg l(−1) of azithromycin can be reduced by the macrophyte P. oceanica when present in the environment at low masses as 10% DW. Elsevier Ltd. 2023-02-15 2023-01-03 /pmc/articles/PMC9808061/ /pubmed/36608722 http://dx.doi.org/10.1016/j.envpol.2023.121007 Text en © 2023 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Badraoui, Riadh Mannai, Ghofrane Siddiqui, Arif J. Pacioglu, Octavian Rudayni, Hassan A. Boufahja, Fehmi Essid, Naceur How toxic is the COVID-19 drug azithromycin in the presence of Posidonia oceanica? Toxicokinetics and experimental approach of meiobenthic nematodes from a metallically pristine area() |
title | How toxic is the COVID-19 drug azithromycin in the presence of Posidonia oceanica? Toxicokinetics and experimental approach of meiobenthic nematodes from a metallically pristine area() |
title_full | How toxic is the COVID-19 drug azithromycin in the presence of Posidonia oceanica? Toxicokinetics and experimental approach of meiobenthic nematodes from a metallically pristine area() |
title_fullStr | How toxic is the COVID-19 drug azithromycin in the presence of Posidonia oceanica? Toxicokinetics and experimental approach of meiobenthic nematodes from a metallically pristine area() |
title_full_unstemmed | How toxic is the COVID-19 drug azithromycin in the presence of Posidonia oceanica? Toxicokinetics and experimental approach of meiobenthic nematodes from a metallically pristine area() |
title_short | How toxic is the COVID-19 drug azithromycin in the presence of Posidonia oceanica? Toxicokinetics and experimental approach of meiobenthic nematodes from a metallically pristine area() |
title_sort | how toxic is the covid-19 drug azithromycin in the presence of posidonia oceanica? toxicokinetics and experimental approach of meiobenthic nematodes from a metallically pristine area() |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808061/ https://www.ncbi.nlm.nih.gov/pubmed/36608722 http://dx.doi.org/10.1016/j.envpol.2023.121007 |
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