Spontaneous Retinal Reperfusion of Capillary Nonperfusion Areas in Diabetic Retinopathy: A Comparative Angiographic Illustration by Fluorescence Fundus Angiography and Optic Coherence Tomography Angiography

PURPOSE: The aim of the study was to describe a case of diabetic macular ischemia developing reperfusion without any treatment involved. OBSERVATIONS: A 35-year-old diabetic lady with well-controlled blood glucose who complained about visual impairment in the left eye. When first seen, she had paramacular retinal nonperfusion on angiographic imaging, together with retinal thinning and intraretinal microvascular abnormalities. Marked reversal of the retinal perfusion occurred within 7 months. Some original nonperfusion areas were reperfused with nearly normal capillary, while some showed revascularized with intraretinal microvascular abnormalities. CONCLUSION AND IMPORTANCE: There were rare reports that diabetic macular nonperfusion areas could be reperfused spontaneously by revascularization. Our case presents an uncommon result of nonperfusion areas with the process being well captured by fundus fluorescein angiography and optic coherence tomography angiography.