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Major Thalassemia, Screening or Treatment: An Economic Evaluation Study in Iran
Background: Beta-thalassemia minor and thalassemia major are an autosomal recessive disease with hypochromic, microcytic anemia, and morbidities, Today, therapeutic advances have significantly improved the life expectancy of thalassemia major patients, but at the cost of financial toxicity. The pres...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Kerman University of Medical Sciences
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808182/ https://www.ncbi.nlm.nih.gov/pubmed/33619933 http://dx.doi.org/10.34172/ijhpm.2021.04 |
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author | Esmaeilzadeh, Firooz Ahmadi, Batoul Vahedi, Sajad Barzegari, Saeed Rajabi, Abdolhalim |
author_facet | Esmaeilzadeh, Firooz Ahmadi, Batoul Vahedi, Sajad Barzegari, Saeed Rajabi, Abdolhalim |
author_sort | Esmaeilzadeh, Firooz |
collection | PubMed |
description | Background: Beta-thalassemia minor and thalassemia major are an autosomal recessive disease with hypochromic, microcytic anemia, and morbidities, Today, therapeutic advances have significantly improved the life expectancy of thalassemia major patients, but at the cost of financial toxicity. The present study aimed to investigate the possibility of increasing the funding for thalassemia screening programs and comparing the cost-effectiveness of screening for thalassemia in the treatment of the patients. Methods: In this study, screening for thalassemia minor was compared with the treatment of thalassemia major patients. A decision tree model was used for analysis. A hospital database, supplemented with a review of published literature, was used to derive input parameters for the model. A lifetime study horizon was used and future costs and consequences were discounted at 3%. The approach of purchases of services was used to evaluate the screening test costs for patients with thalassemia major. Also, a bottom-up method was applied to estimate other screening and treatment costs. All the costs were calculated over one year. The number of gained quality-adjusted life years (QALYs) was calculated using the EQ-5D questionnaire in the evaluated patients. Results: In this study, 26.97 births of patients with thalassemia major were prevented by screening techniques. On the other hand, total screening costs for patients with thalassemia major were estimated equal to US$ 879879, while the costs of preventing the birth of each thalassaemia major patient was US$ 32 624 by screening techniques. In comparison, the cost of managing a patient with thalassemia major is about US$ 136 532 per year. The life time QALYs for this is 11.8 QALYs. Results are presented using a societal perspective. Incremental cost per QALY gained with screening as compared with managing thalassaemia major was US$ 11 571. Conclusion: Screening is a long-term value for money intervention that is highly cost effective and its long-term clinical and economic benefits outweigh those of managing thalassaemia major patients. |
format | Online Article Text |
id | pubmed-9808182 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Kerman University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-98081822023-01-10 Major Thalassemia, Screening or Treatment: An Economic Evaluation Study in Iran Esmaeilzadeh, Firooz Ahmadi, Batoul Vahedi, Sajad Barzegari, Saeed Rajabi, Abdolhalim Int J Health Policy Manag Original Article Background: Beta-thalassemia minor and thalassemia major are an autosomal recessive disease with hypochromic, microcytic anemia, and morbidities, Today, therapeutic advances have significantly improved the life expectancy of thalassemia major patients, but at the cost of financial toxicity. The present study aimed to investigate the possibility of increasing the funding for thalassemia screening programs and comparing the cost-effectiveness of screening for thalassemia in the treatment of the patients. Methods: In this study, screening for thalassemia minor was compared with the treatment of thalassemia major patients. A decision tree model was used for analysis. A hospital database, supplemented with a review of published literature, was used to derive input parameters for the model. A lifetime study horizon was used and future costs and consequences were discounted at 3%. The approach of purchases of services was used to evaluate the screening test costs for patients with thalassemia major. Also, a bottom-up method was applied to estimate other screening and treatment costs. All the costs were calculated over one year. The number of gained quality-adjusted life years (QALYs) was calculated using the EQ-5D questionnaire in the evaluated patients. Results: In this study, 26.97 births of patients with thalassemia major were prevented by screening techniques. On the other hand, total screening costs for patients with thalassemia major were estimated equal to US$ 879879, while the costs of preventing the birth of each thalassaemia major patient was US$ 32 624 by screening techniques. In comparison, the cost of managing a patient with thalassemia major is about US$ 136 532 per year. The life time QALYs for this is 11.8 QALYs. Results are presented using a societal perspective. Incremental cost per QALY gained with screening as compared with managing thalassaemia major was US$ 11 571. Conclusion: Screening is a long-term value for money intervention that is highly cost effective and its long-term clinical and economic benefits outweigh those of managing thalassaemia major patients. Kerman University of Medical Sciences 2021-02-03 /pmc/articles/PMC9808182/ /pubmed/33619933 http://dx.doi.org/10.34172/ijhpm.2021.04 Text en © 2022 The Author(s); Published by Kerman University of Medical Sciences https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Esmaeilzadeh, Firooz Ahmadi, Batoul Vahedi, Sajad Barzegari, Saeed Rajabi, Abdolhalim Major Thalassemia, Screening or Treatment: An Economic Evaluation Study in Iran |
title | Major Thalassemia, Screening or Treatment: An Economic Evaluation Study in Iran |
title_full | Major Thalassemia, Screening or Treatment: An Economic Evaluation Study in Iran |
title_fullStr | Major Thalassemia, Screening or Treatment: An Economic Evaluation Study in Iran |
title_full_unstemmed | Major Thalassemia, Screening or Treatment: An Economic Evaluation Study in Iran |
title_short | Major Thalassemia, Screening or Treatment: An Economic Evaluation Study in Iran |
title_sort | major thalassemia, screening or treatment: an economic evaluation study in iran |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808182/ https://www.ncbi.nlm.nih.gov/pubmed/33619933 http://dx.doi.org/10.34172/ijhpm.2021.04 |
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