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Characterization of Leukemic Resistance to CD19-Targeted CAR T-cell Therapy through Deep Genomic Sequencing

Chimeric antigen receptor (CAR) T-cell therapy targeting CD19 has been a clinical breakthrough for pediatric B-cell acute lymphoblastic leukemia (B-ALL), and loss of the CD19 target antigen on leukemic cells represents a major mechanism of relapse. Previous studies have observed CD19 mutations speci...

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Detalles Bibliográficos
Autores principales:	Chen, Gregory M., Chen, Chia-Hui, Perazzelli, Jessica, Grupp, Stephan A., Barrett, David M., Tan, Kai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Priority Briefs
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808313/ https://www.ncbi.nlm.nih.gov/pubmed/36255409 http://dx.doi.org/10.1158/2326-6066.CIR-22-0095

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