The Bispecific Tumor Antigen-Conditional 4–1BB x 5T4 Agonist, ALG.APV-527, Mediates Strong T-Cell Activation and Potent Antitumor Activity in Preclinical Studies

4–1BB (CD137) is an activation-induced costimulatory receptor that regulates immune responses of activated CD8 T and natural killer cells, by enhancing proliferation, survival, cytolytic activity, and IFNγ production. The ability to induce potent antitumor activity by stimulating 4–1BB on tumor-spec...

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Detalles Bibliográficos
Autores principales: Nelson, Michelle H., Fritzell, Sara, Miller, Robert, Werchau, Doreen, Van Citters, Danielle, Nilsson, Anneli, Misher, Lynda, Ljung, Lill, Bader, Robert, Deronic, Adnan, Chunyk, Allison G., Schultz, Lena, Varas, Laura A., Rose, Nadia, Håkansson, Maria, Gross, Jane, Furebring, Christina, Pavlik, Peter, Sundstedt, Anette, Veitonmäki, Niina, Ramos, Hilario J., Säll, Anna, Dahlman, Anna, Bienvenue, David, von Schantz, Laura, McMahan, Catherine J., Askmyr, Maria, Hernandez-Hoyos, Gabriela, Ellmark, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Large Molecule Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808321/
https://www.ncbi.nlm.nih.gov/pubmed/36343381
http://dx.doi.org/10.1158/1535-7163.MCT-22-0395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808321/
https://www.ncbi.nlm.nih.gov/pubmed/36343381
http://dx.doi.org/10.1158/1535-7163.MCT-22-0395

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