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All-cause admissions following a first ever exacerbation-related hospitalisation in COPD

BACKGROUND: Hospital admissions are important contributors to the overall burden of chronic obstructive pulmonary disease (COPD). Understanding the patterns and causes of hospital admissions will help to identify targets for preventive interventions. This study aimed to determine the 5-year all-caus...

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Autores principales: Waeijen-Smit, Kiki, Jacobsen, Peter A., Houben-Wilke, Sarah, Simons, Sami O., Franssen, Frits M.E., Spruit, Martijn A., Pedersen, Christian T., Kragholm, Kristian H., Weinreich, Ulla M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808537/
https://www.ncbi.nlm.nih.gov/pubmed/36605904
http://dx.doi.org/10.1183/23120541.00217-2022
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author Waeijen-Smit, Kiki
Jacobsen, Peter A.
Houben-Wilke, Sarah
Simons, Sami O.
Franssen, Frits M.E.
Spruit, Martijn A.
Pedersen, Christian T.
Kragholm, Kristian H.
Weinreich, Ulla M.
author_facet Waeijen-Smit, Kiki
Jacobsen, Peter A.
Houben-Wilke, Sarah
Simons, Sami O.
Franssen, Frits M.E.
Spruit, Martijn A.
Pedersen, Christian T.
Kragholm, Kristian H.
Weinreich, Ulla M.
author_sort Waeijen-Smit, Kiki
collection PubMed
description BACKGROUND: Hospital admissions are important contributors to the overall burden of chronic obstructive pulmonary disease (COPD). Understanding the patterns and causes of hospital admissions will help to identify targets for preventive interventions. This study aimed to determine the 5-year all-cause hospital admission trajectories of patients with COPD following their first ever exacerbation-related hospitalisation. METHODS: Patients with COPD were identified from the Danish national registries. Patients experiencing their first ever exacerbation-related hospitalisation, defined as the index event, between 2000 and 2014 were included. All-cause hospital admissions were examined during a subsequent 5-year follow-up period, and categorised using the International Classification of Diseases, 10th revision. RESULTS: In total, 82 964 patients with COPD were included. The mean±sd age was 72±10 years and 48% were male. Comorbidities were present in 58%, and 65% of the patients collected inhalation medication ≤6 months prior to the index event. In total, 337 066 all-cause hospital admissions were identified, resulting in a 5-year admission rate of 82%. Most admissions were due to nonrespiratory causes (59%), amongst which cardiac events were most common (19%). CONCLUSION: Hospital admissions following a first exacerbation-related hospitalisation are common; nonrespiratory events constitute the majority of admissions. Besides the respiratory causes, treatment targeting the nonrespiratory causes of hospital admission should be considered to effectively decrease the burden of hospitalisation in COPD.
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spelling pubmed-98085372023-01-04 All-cause admissions following a first ever exacerbation-related hospitalisation in COPD Waeijen-Smit, Kiki Jacobsen, Peter A. Houben-Wilke, Sarah Simons, Sami O. Franssen, Frits M.E. Spruit, Martijn A. Pedersen, Christian T. Kragholm, Kristian H. Weinreich, Ulla M. ERJ Open Res Original Research Articles BACKGROUND: Hospital admissions are important contributors to the overall burden of chronic obstructive pulmonary disease (COPD). Understanding the patterns and causes of hospital admissions will help to identify targets for preventive interventions. This study aimed to determine the 5-year all-cause hospital admission trajectories of patients with COPD following their first ever exacerbation-related hospitalisation. METHODS: Patients with COPD were identified from the Danish national registries. Patients experiencing their first ever exacerbation-related hospitalisation, defined as the index event, between 2000 and 2014 were included. All-cause hospital admissions were examined during a subsequent 5-year follow-up period, and categorised using the International Classification of Diseases, 10th revision. RESULTS: In total, 82 964 patients with COPD were included. The mean±sd age was 72±10 years and 48% were male. Comorbidities were present in 58%, and 65% of the patients collected inhalation medication ≤6 months prior to the index event. In total, 337 066 all-cause hospital admissions were identified, resulting in a 5-year admission rate of 82%. Most admissions were due to nonrespiratory causes (59%), amongst which cardiac events were most common (19%). CONCLUSION: Hospital admissions following a first exacerbation-related hospitalisation are common; nonrespiratory events constitute the majority of admissions. Besides the respiratory causes, treatment targeting the nonrespiratory causes of hospital admission should be considered to effectively decrease the burden of hospitalisation in COPD. European Respiratory Society 2023-01-03 /pmc/articles/PMC9808537/ /pubmed/36605904 http://dx.doi.org/10.1183/23120541.00217-2022 Text en Copyright ©The authors 2023 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org)
spellingShingle Original Research Articles
Waeijen-Smit, Kiki
Jacobsen, Peter A.
Houben-Wilke, Sarah
Simons, Sami O.
Franssen, Frits M.E.
Spruit, Martijn A.
Pedersen, Christian T.
Kragholm, Kristian H.
Weinreich, Ulla M.
All-cause admissions following a first ever exacerbation-related hospitalisation in COPD
title All-cause admissions following a first ever exacerbation-related hospitalisation in COPD
title_full All-cause admissions following a first ever exacerbation-related hospitalisation in COPD
title_fullStr All-cause admissions following a first ever exacerbation-related hospitalisation in COPD
title_full_unstemmed All-cause admissions following a first ever exacerbation-related hospitalisation in COPD
title_short All-cause admissions following a first ever exacerbation-related hospitalisation in COPD
title_sort all-cause admissions following a first ever exacerbation-related hospitalisation in copd
topic Original Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808537/
https://www.ncbi.nlm.nih.gov/pubmed/36605904
http://dx.doi.org/10.1183/23120541.00217-2022
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