A-MYB/TCFL5 regulatory architecture ensures the production of pachytene piRNAs in placental mammals

In male mice, the transcription factor A-MYB initiates the transcription of pachytene piRNA genes during meiosis. Here, we report that A-MYB activates the transcription factor Tcfl5 produced in pachytene spermatocytes. Subsequently, A-MYB and TCFL5 reciprocally reinforce their own transcription to e...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Tiangxiong, Biasini, Adriano, Cecchini, Katharine, Säflund, Martin, Mou, Haiwei, Arif, Amena, Eghbali, Atiyeh, de Rooij, Dirk G., Weng, Zhiping, Zamore, Phillip D., Özata, Deniz M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808571/
https://www.ncbi.nlm.nih.gov/pubmed/36241367
http://dx.doi.org/10.1261/rna.079472.122

Ejemplares similares

Ejemplares similares