Direct fluoroalkylthiolation of indoles with iodofluoroethane enabled by Na(2)S(2)O(4)

In this paper, we report an efficient approach for the direct fluoroalkylthiolation of indoles with iodofluoroethane in the presence of Na(2)S(2)O(4). In this work, we employed readily available iodofluoroethane and Na(2)S(2)O(4) as fluoroalkylthiolation reagents, featuring mild conditions and a wid...

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Detalles Bibliográficos
Autores principales: Yu, Nianhua, Huang, Jianjian, Leng, Faqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808600/
https://www.ncbi.nlm.nih.gov/pubmed/36683774
http://dx.doi.org/10.1039/d2ra07430c
Descripción
Sumario:In this paper, we report an efficient approach for the direct fluoroalkylthiolation of indoles with iodofluoroethane in the presence of Na(2)S(2)O(4). In this work, we employed readily available iodofluoroethane and Na(2)S(2)O(4) as fluoroalkylthiolation reagents, featuring mild conditions and a wide range of indole substrates. In addition, fluoroalkylthiolated 2,3′-biindole derivatives can also be prepared by this method.

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