Direct fluoroalkylthiolation of indoles with iodofluoroethane enabled by Na(2)S(2)O(4)

In this paper, we report an efficient approach for the direct fluoroalkylthiolation of indoles with iodofluoroethane in the presence of Na(2)S(2)O(4). In this work, we employed readily available iodofluoroethane and Na(2)S(2)O(4) as fluoroalkylthiolation reagents, featuring mild conditions and a wid...

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Detalles Bibliográficos
Autores principales: Yu, Nianhua, Huang, Jianjian, Leng, Faqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808600/
https://www.ncbi.nlm.nih.gov/pubmed/36683774
http://dx.doi.org/10.1039/d2ra07430c
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author Yu, Nianhua
Huang, Jianjian
Leng, Faqiang
author_facet Yu, Nianhua
Huang, Jianjian
Leng, Faqiang
author_sort Yu, Nianhua
collection PubMed
description In this paper, we report an efficient approach for the direct fluoroalkylthiolation of indoles with iodofluoroethane in the presence of Na(2)S(2)O(4). In this work, we employed readily available iodofluoroethane and Na(2)S(2)O(4) as fluoroalkylthiolation reagents, featuring mild conditions and a wide range of indole substrates. In addition, fluoroalkylthiolated 2,3′-biindole derivatives can also be prepared by this method.
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spelling pubmed-98086002023-01-20 Direct fluoroalkylthiolation of indoles with iodofluoroethane enabled by Na(2)S(2)O(4) Yu, Nianhua Huang, Jianjian Leng, Faqiang RSC Adv Chemistry In this paper, we report an efficient approach for the direct fluoroalkylthiolation of indoles with iodofluoroethane in the presence of Na(2)S(2)O(4). In this work, we employed readily available iodofluoroethane and Na(2)S(2)O(4) as fluoroalkylthiolation reagents, featuring mild conditions and a wide range of indole substrates. In addition, fluoroalkylthiolated 2,3′-biindole derivatives can also be prepared by this method. The Royal Society of Chemistry 2023-01-03 /pmc/articles/PMC9808600/ /pubmed/36683774 http://dx.doi.org/10.1039/d2ra07430c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Yu, Nianhua
Huang, Jianjian
Leng, Faqiang
Direct fluoroalkylthiolation of indoles with iodofluoroethane enabled by Na(2)S(2)O(4)
title Direct fluoroalkylthiolation of indoles with iodofluoroethane enabled by Na(2)S(2)O(4)
title_full Direct fluoroalkylthiolation of indoles with iodofluoroethane enabled by Na(2)S(2)O(4)
title_fullStr Direct fluoroalkylthiolation of indoles with iodofluoroethane enabled by Na(2)S(2)O(4)
title_full_unstemmed Direct fluoroalkylthiolation of indoles with iodofluoroethane enabled by Na(2)S(2)O(4)
title_short Direct fluoroalkylthiolation of indoles with iodofluoroethane enabled by Na(2)S(2)O(4)
title_sort direct fluoroalkylthiolation of indoles with iodofluoroethane enabled by na(2)s(2)o(4)
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808600/
https://www.ncbi.nlm.nih.gov/pubmed/36683774
http://dx.doi.org/10.1039/d2ra07430c
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AT huangjianjian directfluoroalkylthiolationofindoleswithiodofluoroethaneenabledbyna2s2o4
AT lengfaqiang directfluoroalkylthiolationofindoleswithiodofluoroethaneenabledbyna2s2o4

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