Cargando…

Association between P-Selectin Autoantibody Positive and Response to Steroid Treatment in Newly Diagnosed Immune Thrombocytopenia Patients

OBJECTIVE: This study aimed to detect the association between P-selectin autoantibody positive and response to steroid treatment in newly diagnosed immune thrombocytopenia (ITP) patients. METHODS: The data from 105 newly diagnosed adult ITP patients administered with first-line of steroid treatment...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Li, Wang, Dong-Dong, Jiao, Rui-Ying, Liu, Chang-Xun, Hou, Yan-Qiu, Qin, Hui, He, Hong-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808632/
https://www.ncbi.nlm.nih.gov/pubmed/35405676
http://dx.doi.org/10.1159/000524535
_version_ 1784862974019633152
author Wang, Li
Wang, Dong-Dong
Jiao, Rui-Ying
Liu, Chang-Xun
Hou, Yan-Qiu
Qin, Hui
He, Hong-Jie
author_facet Wang, Li
Wang, Dong-Dong
Jiao, Rui-Ying
Liu, Chang-Xun
Hou, Yan-Qiu
Qin, Hui
He, Hong-Jie
author_sort Wang, Li
collection PubMed
description OBJECTIVE: This study aimed to detect the association between P-selectin autoantibody positive and response to steroid treatment in newly diagnosed immune thrombocytopenia (ITP) patients. METHODS: The data from 105 newly diagnosed adult ITP patients administered with first-line of steroid treatment from October 2016 to May 2021 were retrospectively analyzed. Treatment responses were evaluated within 3 months after the onset of treatment. RESULTS: Among the 105 patients, 80.00% (84/105) of patients presented with platelet glycoprotein-specific antibody positive; 44.76% (47/105) patients were anti-P-selectin positive, while 35.24% (37/105) were anti-P-selectin negative. No significant difference in overall response was observed between patients who were anti-P-selectin positive and those who were anti-P-selectin negative (74.47% vs. 89.19, χ<sup>2</sup> = 2.910, p = 0.088). But patients who were anti-P-selectin negative had significantly higher complete response rate, compared to those who were anti-P-selectin positive (72.97% vs. 48.94%, χ<sup>2</sup> = 4,965, p = 0.026). Logistic regression analysis revealed that anti-GP IIb/IIIa positive (OR = 3.114, p = 0.010, 95% CI: 1.313–7.388) and anti-P-selectin positive (OR = 0.309, p = 0.036, 95% CI: 0.127–0.753) were two factors that could affect patients' response. CONCLUSIONS: Our study found that ITP patients with anti-GP IIb/IIIa may have a higher response to steroid treatment, but anti-P-selectin-mediated-ITP might be less responsive to steroid treatment. In adults with ITP, the presence of anti-P-selectin autoantibodies is a predictive factor for poor response to steroid treatment.
format Online
Article
Text
id pubmed-9808632
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher S. Karger AG
record_format MEDLINE/PubMed
spelling pubmed-98086322023-01-04 Association between P-Selectin Autoantibody Positive and Response to Steroid Treatment in Newly Diagnosed Immune Thrombocytopenia Patients Wang, Li Wang, Dong-Dong Jiao, Rui-Ying Liu, Chang-Xun Hou, Yan-Qiu Qin, Hui He, Hong-Jie Acta Haematol Original Paper OBJECTIVE: This study aimed to detect the association between P-selectin autoantibody positive and response to steroid treatment in newly diagnosed immune thrombocytopenia (ITP) patients. METHODS: The data from 105 newly diagnosed adult ITP patients administered with first-line of steroid treatment from October 2016 to May 2021 were retrospectively analyzed. Treatment responses were evaluated within 3 months after the onset of treatment. RESULTS: Among the 105 patients, 80.00% (84/105) of patients presented with platelet glycoprotein-specific antibody positive; 44.76% (47/105) patients were anti-P-selectin positive, while 35.24% (37/105) were anti-P-selectin negative. No significant difference in overall response was observed between patients who were anti-P-selectin positive and those who were anti-P-selectin negative (74.47% vs. 89.19, χ<sup>2</sup> = 2.910, p = 0.088). But patients who were anti-P-selectin negative had significantly higher complete response rate, compared to those who were anti-P-selectin positive (72.97% vs. 48.94%, χ<sup>2</sup> = 4,965, p = 0.026). Logistic regression analysis revealed that anti-GP IIb/IIIa positive (OR = 3.114, p = 0.010, 95% CI: 1.313–7.388) and anti-P-selectin positive (OR = 0.309, p = 0.036, 95% CI: 0.127–0.753) were two factors that could affect patients' response. CONCLUSIONS: Our study found that ITP patients with anti-GP IIb/IIIa may have a higher response to steroid treatment, but anti-P-selectin-mediated-ITP might be less responsive to steroid treatment. In adults with ITP, the presence of anti-P-selectin autoantibodies is a predictive factor for poor response to steroid treatment. S. Karger AG 2022-09 2022-04-11 /pmc/articles/PMC9808632/ /pubmed/35405676 http://dx.doi.org/10.1159/000524535 Text en The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc-nd/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission.
spellingShingle Original Paper
Wang, Li
Wang, Dong-Dong
Jiao, Rui-Ying
Liu, Chang-Xun
Hou, Yan-Qiu
Qin, Hui
He, Hong-Jie
Association between P-Selectin Autoantibody Positive and Response to Steroid Treatment in Newly Diagnosed Immune Thrombocytopenia Patients
title Association between P-Selectin Autoantibody Positive and Response to Steroid Treatment in Newly Diagnosed Immune Thrombocytopenia Patients
title_full Association between P-Selectin Autoantibody Positive and Response to Steroid Treatment in Newly Diagnosed Immune Thrombocytopenia Patients
title_fullStr Association between P-Selectin Autoantibody Positive and Response to Steroid Treatment in Newly Diagnosed Immune Thrombocytopenia Patients
title_full_unstemmed Association between P-Selectin Autoantibody Positive and Response to Steroid Treatment in Newly Diagnosed Immune Thrombocytopenia Patients
title_short Association between P-Selectin Autoantibody Positive and Response to Steroid Treatment in Newly Diagnosed Immune Thrombocytopenia Patients
title_sort association between p-selectin autoantibody positive and response to steroid treatment in newly diagnosed immune thrombocytopenia patients
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808632/
https://www.ncbi.nlm.nih.gov/pubmed/35405676
http://dx.doi.org/10.1159/000524535
work_keys_str_mv AT wangli associationbetweenpselectinautoantibodypositiveandresponsetosteroidtreatmentinnewlydiagnosedimmunethrombocytopeniapatients
AT wangdongdong associationbetweenpselectinautoantibodypositiveandresponsetosteroidtreatmentinnewlydiagnosedimmunethrombocytopeniapatients
AT jiaoruiying associationbetweenpselectinautoantibodypositiveandresponsetosteroidtreatmentinnewlydiagnosedimmunethrombocytopeniapatients
AT liuchangxun associationbetweenpselectinautoantibodypositiveandresponsetosteroidtreatmentinnewlydiagnosedimmunethrombocytopeniapatients
AT houyanqiu associationbetweenpselectinautoantibodypositiveandresponsetosteroidtreatmentinnewlydiagnosedimmunethrombocytopeniapatients
AT qinhui associationbetweenpselectinautoantibodypositiveandresponsetosteroidtreatmentinnewlydiagnosedimmunethrombocytopeniapatients
AT hehongjie associationbetweenpselectinautoantibodypositiveandresponsetosteroidtreatmentinnewlydiagnosedimmunethrombocytopeniapatients