Cargando…

Retinal Vessel Phenotype in Patients with a History of Retinal Vein Occlusion

INTRODUCTION: The aim of the study was to estimate the phenotype of retinal vessels using central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), tortuosity, and fractal analysis in the unaffected contralateral eye of patients with central or branch retinal vein occlusion (...

Descripción completa

Detalles Bibliográficos
Autores principales: Semecas, Rachel, Arnould, Louis, Aptel, Florent, Gavard, Olivier, Mautuit, Thibaud, Creuzot-Garcher, Catherine, Bron, Alain, MacGillivray, Tom, Hogg, Stephen, Trucco, Emmanuel, Chiquet, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808644/
https://www.ncbi.nlm.nih.gov/pubmed/33910213
http://dx.doi.org/10.1159/000516235
_version_ 1784862976526778368
author Semecas, Rachel
Arnould, Louis
Aptel, Florent
Gavard, Olivier
Mautuit, Thibaud
Creuzot-Garcher, Catherine
Bron, Alain
MacGillivray, Tom
Hogg, Stephen
Trucco, Emmanuel
Chiquet, Christophe
author_facet Semecas, Rachel
Arnould, Louis
Aptel, Florent
Gavard, Olivier
Mautuit, Thibaud
Creuzot-Garcher, Catherine
Bron, Alain
MacGillivray, Tom
Hogg, Stephen
Trucco, Emmanuel
Chiquet, Christophe
author_sort Semecas, Rachel
collection PubMed
description INTRODUCTION: The aim of the study was to estimate the phenotype of retinal vessels using central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), tortuosity, and fractal analysis in the unaffected contralateral eye of patients with central or branch retinal vein occlusion (CRVO or BRVO). METHODS: Thirty-four patients suffering from CRVO, 15 suffering from BRVO, and 49 controlled matched subjects had a fundus image analyzed using the VAMPIRE software. The intraclass correlation coefficient and a Bland-Altman plot were done for the reproducibility study. RESULTS: There was a lack of evidence of difference between the control group and the CRVO group for CRAE (p = 0.06), CRVE (p = 0.3), and arterio-venule ratio (AVR, p = 0.6). Contralateral eyes of CRVO exhibited a significantly higher arterial and minimum arterial tortuosity values (p = 0.012), as compared with control eyes. Contralateral eyes of patients with a history of BRVO had a significantly higher CRAE (p = 0.02), AVR (p = 0.006), and minimal arterial tortuosity (p = 0.05). Fractal analysis showed that contralateral eyes of BRVO had higher values of fractal parameters (D0a, p = 0.005). CONCLUSION: This study suggests that CVRO or BRVO is not triggered by the same retinal vascular phenotypes in the contralateral eye. The morphology of retinal vasculature may be associated with the occurrence of RVO, independently of known risk factors.
format Online
Article
Text
id pubmed-9808644
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher S. Karger AG
record_format MEDLINE/PubMed
spelling pubmed-98086442023-01-04 Retinal Vessel Phenotype in Patients with a History of Retinal Vein Occlusion Semecas, Rachel Arnould, Louis Aptel, Florent Gavard, Olivier Mautuit, Thibaud Creuzot-Garcher, Catherine Bron, Alain MacGillivray, Tom Hogg, Stephen Trucco, Emmanuel Chiquet, Christophe Ophthalmic Res Research Article INTRODUCTION: The aim of the study was to estimate the phenotype of retinal vessels using central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), tortuosity, and fractal analysis in the unaffected contralateral eye of patients with central or branch retinal vein occlusion (CRVO or BRVO). METHODS: Thirty-four patients suffering from CRVO, 15 suffering from BRVO, and 49 controlled matched subjects had a fundus image analyzed using the VAMPIRE software. The intraclass correlation coefficient and a Bland-Altman plot were done for the reproducibility study. RESULTS: There was a lack of evidence of difference between the control group and the CRVO group for CRAE (p = 0.06), CRVE (p = 0.3), and arterio-venule ratio (AVR, p = 0.6). Contralateral eyes of CRVO exhibited a significantly higher arterial and minimum arterial tortuosity values (p = 0.012), as compared with control eyes. Contralateral eyes of patients with a history of BRVO had a significantly higher CRAE (p = 0.02), AVR (p = 0.006), and minimal arterial tortuosity (p = 0.05). Fractal analysis showed that contralateral eyes of BRVO had higher values of fractal parameters (D0a, p = 0.005). CONCLUSION: This study suggests that CVRO or BRVO is not triggered by the same retinal vascular phenotypes in the contralateral eye. The morphology of retinal vasculature may be associated with the occurrence of RVO, independently of known risk factors. S. Karger AG 2021-04-28 /pmc/articles/PMC9808644/ /pubmed/33910213 http://dx.doi.org/10.1159/000516235 Text en Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission.
spellingShingle Research Article
Semecas, Rachel
Arnould, Louis
Aptel, Florent
Gavard, Olivier
Mautuit, Thibaud
Creuzot-Garcher, Catherine
Bron, Alain
MacGillivray, Tom
Hogg, Stephen
Trucco, Emmanuel
Chiquet, Christophe
Retinal Vessel Phenotype in Patients with a History of Retinal Vein Occlusion
title Retinal Vessel Phenotype in Patients with a History of Retinal Vein Occlusion
title_full Retinal Vessel Phenotype in Patients with a History of Retinal Vein Occlusion
title_fullStr Retinal Vessel Phenotype in Patients with a History of Retinal Vein Occlusion
title_full_unstemmed Retinal Vessel Phenotype in Patients with a History of Retinal Vein Occlusion
title_short Retinal Vessel Phenotype in Patients with a History of Retinal Vein Occlusion
title_sort retinal vessel phenotype in patients with a history of retinal vein occlusion
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808644/
https://www.ncbi.nlm.nih.gov/pubmed/33910213
http://dx.doi.org/10.1159/000516235
work_keys_str_mv AT semecasrachel retinalvesselphenotypeinpatientswithahistoryofretinalveinocclusion
AT arnouldlouis retinalvesselphenotypeinpatientswithahistoryofretinalveinocclusion
AT aptelflorent retinalvesselphenotypeinpatientswithahistoryofretinalveinocclusion
AT gavardolivier retinalvesselphenotypeinpatientswithahistoryofretinalveinocclusion
AT mautuitthibaud retinalvesselphenotypeinpatientswithahistoryofretinalveinocclusion
AT creuzotgarchercatherine retinalvesselphenotypeinpatientswithahistoryofretinalveinocclusion
AT bronalain retinalvesselphenotypeinpatientswithahistoryofretinalveinocclusion
AT macgillivraytom retinalvesselphenotypeinpatientswithahistoryofretinalveinocclusion
AT hoggstephen retinalvesselphenotypeinpatientswithahistoryofretinalveinocclusion
AT truccoemmanuel retinalvesselphenotypeinpatientswithahistoryofretinalveinocclusion
AT chiquetchristophe retinalvesselphenotypeinpatientswithahistoryofretinalveinocclusion