Bone morphogenetic protein 4 inhibits pulmonary fibrosis by modulating cellular senescence and mitophagy in lung fibroblasts

BACKGROUND: Accumulation of myofibroblasts is critical to fibrogenesis in idiopathic pulmonary fibrosis (IPF). Senescence and insufficient mitophagy in fibroblasts contribute to their differentiation into myofibroblasts, thereby promoting the development of lung fibrosis. Bone morphogenetic protein...

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Detalles Bibliográficos
Autores principales: Guan, Ruijuan, Yuan, Liang, Li, Jingpei, Wang, Jian, Li, Ziying, Cai, Zhou, Guo, Hua, Fang, Yaowei, Lin, Ran, Liu, Wei, Wang, Lan, Zheng, Qiuyu, Xu, Jingyi, Zhou, You, Qian, Jing, Ding, Mingjing, Luo, Jieping, Li, Yuanyuan, Yang, Kai, Sun, Dejun, Yao, Hongwei, He, Jianxing, Lu, Wenju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2022
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808813/
https://www.ncbi.nlm.nih.gov/pubmed/35777761
http://dx.doi.org/10.1183/13993003.02307-2021

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