Randomized, Ascending Dose, Phase 2 Study of KHK4083, an Anti-OX40 Monoclonal Antibody, in Moderately Active Ulcerative Colitis

BACKGROUND: OX40 (CD134) plays a role in the maintenance of late T-cell proliferation and survival. KHK4083 is a monoclonal antibody directed against OX40. We aimed to assess the safety and preliminary efficacy of KHK4083 in patients with moderately active ulcerative colitis (UC). METHODS: In this m...

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Detalles Bibliográficos
Autores principales: Kierkus, Jaroslaw, Pesegova, Marina, Klopocka, Maria, Brankovic, Marija, Kasai, Noriyuki, Efuni, Sergey, Kong, Jennifer, Nakajima, Yu, Jordan, Christina, Matsui, Takeshi, Feagan, Brian G, Strout, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Observations and Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808818/
https://www.ncbi.nlm.nih.gov/pubmed/36776497
http://dx.doi.org/10.1093/crocol/otaa049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808818/
https://www.ncbi.nlm.nih.gov/pubmed/36776497
http://dx.doi.org/10.1093/crocol/otaa049

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