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Melatonin receptors and Per1 expression in the inferior olivary nucleus of the Sapajus apella monkey

Melatonin is a transducer of photic environmental information and participates in the synchronization of various physiological and behavioral phenomena. Melatonin can act directly in several areas of the central nervous system through its membrane receptors coupled to G protein, called MT1 and MT2 r...

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Autores principales: Granado, Marcos Donizete Junior, Pinato, Luciana, Santiago, Jeferson, Barbalho, Sandra Maria, Parmezzan, Jessica Ellen Lima, Suzuki, Lenita Mayumi, Cabrini, Mayara Longui, Spressão, Daniele Raineri Mesquita Serva, Carneiro de Camargo, Ana Letícia, Guissoni Campos, Leila Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809291/
https://www.ncbi.nlm.nih.gov/pubmed/36605547
http://dx.doi.org/10.3389/fnins.2022.1072772
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author Granado, Marcos Donizete Junior
Pinato, Luciana
Santiago, Jeferson
Barbalho, Sandra Maria
Parmezzan, Jessica Ellen Lima
Suzuki, Lenita Mayumi
Cabrini, Mayara Longui
Spressão, Daniele Raineri Mesquita Serva
Carneiro de Camargo, Ana Letícia
Guissoni Campos, Leila Maria
author_facet Granado, Marcos Donizete Junior
Pinato, Luciana
Santiago, Jeferson
Barbalho, Sandra Maria
Parmezzan, Jessica Ellen Lima
Suzuki, Lenita Mayumi
Cabrini, Mayara Longui
Spressão, Daniele Raineri Mesquita Serva
Carneiro de Camargo, Ana Letícia
Guissoni Campos, Leila Maria
author_sort Granado, Marcos Donizete Junior
collection PubMed
description Melatonin is a transducer of photic environmental information and participates in the synchronization of various physiological and behavioral phenomena. Melatonin can act directly in several areas of the central nervous system through its membrane receptors coupled to G protein, called MT1 and MT2 receptors. In some structures, such as the retina, hypothalamus and pars tuberalis, the expression of both melatonin receptors shows circadian variations. Melatonin can act in the synchronization of the clock proteins rhythm in these areas. Using the immunohistochemistry technique, we detected the immunoexpression of the melatonin receptors and clock genes clock protein Per1 in the inferior olivary nucleus (ION) of the Sapajus apella monkey at specific times of the light-dark phase. The mapping performed by immunohistochemistry showed expressive immunoreactivity (IR) Per1 with predominance during daytime. Both melatonin receptors were expressed in the ION without a day/night difference. The presence of both melatonin receptors and the Per1 protein in the inferior olivary nucleus can indicate a functional role not only in physiological, as in sleep, anxiety, and circadian rhythm, but also a chronobiotic role in motor control mechanisms.
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spelling pubmed-98092912023-01-04 Melatonin receptors and Per1 expression in the inferior olivary nucleus of the Sapajus apella monkey Granado, Marcos Donizete Junior Pinato, Luciana Santiago, Jeferson Barbalho, Sandra Maria Parmezzan, Jessica Ellen Lima Suzuki, Lenita Mayumi Cabrini, Mayara Longui Spressão, Daniele Raineri Mesquita Serva Carneiro de Camargo, Ana Letícia Guissoni Campos, Leila Maria Front Neurosci Neuroscience Melatonin is a transducer of photic environmental information and participates in the synchronization of various physiological and behavioral phenomena. Melatonin can act directly in several areas of the central nervous system through its membrane receptors coupled to G protein, called MT1 and MT2 receptors. In some structures, such as the retina, hypothalamus and pars tuberalis, the expression of both melatonin receptors shows circadian variations. Melatonin can act in the synchronization of the clock proteins rhythm in these areas. Using the immunohistochemistry technique, we detected the immunoexpression of the melatonin receptors and clock genes clock protein Per1 in the inferior olivary nucleus (ION) of the Sapajus apella monkey at specific times of the light-dark phase. The mapping performed by immunohistochemistry showed expressive immunoreactivity (IR) Per1 with predominance during daytime. Both melatonin receptors were expressed in the ION without a day/night difference. The presence of both melatonin receptors and the Per1 protein in the inferior olivary nucleus can indicate a functional role not only in physiological, as in sleep, anxiety, and circadian rhythm, but also a chronobiotic role in motor control mechanisms. Frontiers Media S.A. 2022-12-20 /pmc/articles/PMC9809291/ /pubmed/36605547 http://dx.doi.org/10.3389/fnins.2022.1072772 Text en Copyright © 2022 Granado, Pinato, Santiago, Barbalho, Parmezzan, Suzuki, Cabrini, Spressão, Carneiro de Camargo and Guissoni Campos. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Granado, Marcos Donizete Junior
Pinato, Luciana
Santiago, Jeferson
Barbalho, Sandra Maria
Parmezzan, Jessica Ellen Lima
Suzuki, Lenita Mayumi
Cabrini, Mayara Longui
Spressão, Daniele Raineri Mesquita Serva
Carneiro de Camargo, Ana Letícia
Guissoni Campos, Leila Maria
Melatonin receptors and Per1 expression in the inferior olivary nucleus of the Sapajus apella monkey
title Melatonin receptors and Per1 expression in the inferior olivary nucleus of the Sapajus apella monkey
title_full Melatonin receptors and Per1 expression in the inferior olivary nucleus of the Sapajus apella monkey
title_fullStr Melatonin receptors and Per1 expression in the inferior olivary nucleus of the Sapajus apella monkey
title_full_unstemmed Melatonin receptors and Per1 expression in the inferior olivary nucleus of the Sapajus apella monkey
title_short Melatonin receptors and Per1 expression in the inferior olivary nucleus of the Sapajus apella monkey
title_sort melatonin receptors and per1 expression in the inferior olivary nucleus of the sapajus apella monkey
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809291/
https://www.ncbi.nlm.nih.gov/pubmed/36605547
http://dx.doi.org/10.3389/fnins.2022.1072772
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