Understanding the Dual Roles of CircHIPK3 in Tumorigenesis and Tumor Progression

CircHIPK3 is a type of endogenous circular RNA, which contains a covalently closed circular structure and cannot encode protein or polypeptide. CircHIPK3 is unusually expressed in varieties of tumors and plays dual roles of tumor promotion or tumor inhibition in tumorigenesis and development of tumo...

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Detalles Bibliográficos
Autores principales: Wei, Zeyu, Shi, Yijia, Xue, Changning, Li, Mengna, Wei, Jianxia, Li, Guiyuan, Xiong, Wei, Zhou, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809309/
https://www.ncbi.nlm.nih.gov/pubmed/36606192
http://dx.doi.org/10.7150/jca.78090
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author Wei, Zeyu
Shi, Yijia
Xue, Changning
Li, Mengna
Wei, Jianxia
Li, Guiyuan
Xiong, Wei
Zhou, Ming
author_facet Wei, Zeyu
Shi, Yijia
Xue, Changning
Li, Mengna
Wei, Jianxia
Li, Guiyuan
Xiong, Wei
Zhou, Ming
author_sort Wei, Zeyu
collection PubMed
description CircHIPK3 is a type of endogenous circular RNA, which contains a covalently closed circular structure and cannot encode protein or polypeptide. CircHIPK3 is unusually expressed in varieties of tumors and plays dual roles of tumor promotion or tumor inhibition in tumorigenesis and development of tumors by serving as the sponge for miRNA in multiple tumors. Here, we reviewed the differential expression, the dual functions, the regulation mechanism, and the network in a variety of tumors as well as the potential value for the diagnosis and treatment of tumors, which are of great significance for our comprehensive understanding of the roles and mechanisms of circHIPK3 in tumors.
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spelling pubmed-98093092023-01-04 Understanding the Dual Roles of CircHIPK3 in Tumorigenesis and Tumor Progression Wei, Zeyu Shi, Yijia Xue, Changning Li, Mengna Wei, Jianxia Li, Guiyuan Xiong, Wei Zhou, Ming J Cancer Review CircHIPK3 is a type of endogenous circular RNA, which contains a covalently closed circular structure and cannot encode protein or polypeptide. CircHIPK3 is unusually expressed in varieties of tumors and plays dual roles of tumor promotion or tumor inhibition in tumorigenesis and development of tumors by serving as the sponge for miRNA in multiple tumors. Here, we reviewed the differential expression, the dual functions, the regulation mechanism, and the network in a variety of tumors as well as the potential value for the diagnosis and treatment of tumors, which are of great significance for our comprehensive understanding of the roles and mechanisms of circHIPK3 in tumors. Ivyspring International Publisher 2022-11-28 /pmc/articles/PMC9809309/ /pubmed/36606192 http://dx.doi.org/10.7150/jca.78090 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Wei, Zeyu
Shi, Yijia
Xue, Changning
Li, Mengna
Wei, Jianxia
Li, Guiyuan
Xiong, Wei
Zhou, Ming
Understanding the Dual Roles of CircHIPK3 in Tumorigenesis and Tumor Progression
title Understanding the Dual Roles of CircHIPK3 in Tumorigenesis and Tumor Progression
title_full Understanding the Dual Roles of CircHIPK3 in Tumorigenesis and Tumor Progression
title_fullStr Understanding the Dual Roles of CircHIPK3 in Tumorigenesis and Tumor Progression
title_full_unstemmed Understanding the Dual Roles of CircHIPK3 in Tumorigenesis and Tumor Progression
title_short Understanding the Dual Roles of CircHIPK3 in Tumorigenesis and Tumor Progression
title_sort understanding the dual roles of circhipk3 in tumorigenesis and tumor progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809309/
https://www.ncbi.nlm.nih.gov/pubmed/36606192
http://dx.doi.org/10.7150/jca.78090
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