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Yap signalling regulates ductular reactions in mice with CRISPR/Cas9-induced glycogen storage disease type Ia

Glycogen storage disease type Ia (GSD-Ia) is caused by a deficiency in the glucose-6-phosphatase (G6Pase, G6pc) enzyme, which catalyses the final step of gluconeogenesis and glycogenolysis. Accumulation of G6pc can lead to an increase in glycogen and development of fatty liver. Ductular reactions re...

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Detalles Bibliográficos
Autores principales: Xie, Yixia, Hu, Baowei, Gao, Yue, Tang, Yaxin, Chen, Guohe, Shen, Jiayuan, Jiang, Zhikai, Jiang, He, Han, Jiwei, Yan, Junyan, Jin, Lifang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809376/
https://www.ncbi.nlm.nih.gov/pubmed/36605584
http://dx.doi.org/10.1080/19768354.2022.2139755