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LRRK2 decreases microglial actin dynamics by filamentous actin depolymerization and Rac1 inhibition
An active actin dynamic is a crucial feature of brain microglia. Here we report that LRRK2, a primary familial Parkinson’s disease-associated gene, negatively regulates microglia’s actin dynamics. LRRK2 depolymerized filamentous actin (F-actin) by directly binding to it or inhibiting microglia’s Rac...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809388/ https://www.ncbi.nlm.nih.gov/pubmed/36605588 http://dx.doi.org/10.1080/19768354.2022.2158219 |