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NRAS Gene Mutation in Differentiated High-Grade Thyroid Carcinoma With Multiphenotypic Metastatic Pattern: A Case Report
Differentiated high-grade thyroid carcinoma (DHGTC) has a high mitotic count (≥5 mitoses per 2mm(2)) and/or tumor necrosis without anaplastic features. These tumors are rare, and the prevalence is not yet established among thyroid malignancies. BRAF andRAS mutations are the main driver mutations in...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809503/ https://www.ncbi.nlm.nih.gov/pubmed/36605054 http://dx.doi.org/10.7759/cureus.32177 |
Sumario: | Differentiated high-grade thyroid carcinoma (DHGTC) has a high mitotic count (≥5 mitoses per 2mm(2)) and/or tumor necrosis without anaplastic features. These tumors are rare, and the prevalence is not yet established among thyroid malignancies. BRAF andRAS mutations are the main driver mutations in these tumors. We present a case of a 43-year-old woman with DHGTC and NRASmutation, presenting with metastatic follicular component to the bone and papillary component to lymph nodes. |
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