NRAS Gene Mutation in Differentiated High-Grade Thyroid Carcinoma With Multiphenotypic Metastatic Pattern: A Case Report

Differentiated high-grade thyroid carcinoma (DHGTC) has a high mitotic count (≥5 mitoses per 2mm(2)) and/or tumor necrosis without anaplastic features. These tumors are rare, and the prevalence is not yet established among thyroid malignancies. BRAF andRAS mutations are the main driver mutations in...

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Autores principales: Alvarez Moreno, Juan C, Muthukumarana, Palawinnage, Qiu, Suimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809503/
https://www.ncbi.nlm.nih.gov/pubmed/36605054
http://dx.doi.org/10.7759/cureus.32177
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author Alvarez Moreno, Juan C
Muthukumarana, Palawinnage
Qiu, Suimin
author_facet Alvarez Moreno, Juan C
Muthukumarana, Palawinnage
Qiu, Suimin
author_sort Alvarez Moreno, Juan C
collection PubMed
description Differentiated high-grade thyroid carcinoma (DHGTC) has a high mitotic count (≥5 mitoses per 2mm(2)) and/or tumor necrosis without anaplastic features. These tumors are rare, and the prevalence is not yet established among thyroid malignancies. BRAF andRAS mutations are the main driver mutations in these tumors. We present a case of a 43-year-old woman with DHGTC and NRASmutation, presenting with metastatic follicular component to the bone and papillary component to lymph nodes.
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spelling pubmed-98095032023-01-04 NRAS Gene Mutation in Differentiated High-Grade Thyroid Carcinoma With Multiphenotypic Metastatic Pattern: A Case Report Alvarez Moreno, Juan C Muthukumarana, Palawinnage Qiu, Suimin Cureus Pathology Differentiated high-grade thyroid carcinoma (DHGTC) has a high mitotic count (≥5 mitoses per 2mm(2)) and/or tumor necrosis without anaplastic features. These tumors are rare, and the prevalence is not yet established among thyroid malignancies. BRAF andRAS mutations are the main driver mutations in these tumors. We present a case of a 43-year-old woman with DHGTC and NRASmutation, presenting with metastatic follicular component to the bone and papillary component to lymph nodes. Cureus 2022-12-04 /pmc/articles/PMC9809503/ /pubmed/36605054 http://dx.doi.org/10.7759/cureus.32177 Text en Copyright © 2022, Alvarez Moreno et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pathology
Alvarez Moreno, Juan C
Muthukumarana, Palawinnage
Qiu, Suimin
NRAS Gene Mutation in Differentiated High-Grade Thyroid Carcinoma With Multiphenotypic Metastatic Pattern: A Case Report
title NRAS Gene Mutation in Differentiated High-Grade Thyroid Carcinoma With Multiphenotypic Metastatic Pattern: A Case Report
title_full NRAS Gene Mutation in Differentiated High-Grade Thyroid Carcinoma With Multiphenotypic Metastatic Pattern: A Case Report
title_fullStr NRAS Gene Mutation in Differentiated High-Grade Thyroid Carcinoma With Multiphenotypic Metastatic Pattern: A Case Report
title_full_unstemmed NRAS Gene Mutation in Differentiated High-Grade Thyroid Carcinoma With Multiphenotypic Metastatic Pattern: A Case Report
title_short NRAS Gene Mutation in Differentiated High-Grade Thyroid Carcinoma With Multiphenotypic Metastatic Pattern: A Case Report
title_sort nras gene mutation in differentiated high-grade thyroid carcinoma with multiphenotypic metastatic pattern: a case report
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809503/
https://www.ncbi.nlm.nih.gov/pubmed/36605054
http://dx.doi.org/10.7759/cureus.32177
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AT qiusuimin nrasgenemutationindifferentiatedhighgradethyroidcarcinomawithmultiphenotypicmetastaticpatternacasereport

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