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Combination of metformin/efavirenz/fluoxetine exhibits profound anticancer activity via a cancer cell-specific ROS amplification

The possible anticancer activity of combination (M + E + F) of metformin (M), efavirenz (E), and fluoxetine (F) was investigated in normal HDF cells and HCT116 human colon cancer cells. Metformin increased cellular FOXO3a, p-FOXO3a, AMPK, p-AMPK, and MnSOD levels in HDFs but not in HCT116 cells. Cel...

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Detalles Bibliográficos
Autores principales:	Kang, Beom-Goo, Shende, Madhuri, Inci, Gozde, Park, Soo-Hyun, Jung, Jun-Sub, Kim, Set Byeol, Kim, Jeong Hoon, Mo, Young Won, Seo, Ji-Hyeon, Feng, Jing-Hui, Kim, Sung-Chan, Lim, Soon Sung, Suh, Hong-Won, Lee, Jae-Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809943/ https://www.ncbi.nlm.nih.gov/pubmed/36588385 http://dx.doi.org/10.1080/15384047.2022.2161803

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