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Abnormal triaging of misfolded proteins by adult neuronal ceroid lipofuscinosis-associated DNAJC5/CSPα mutants causes lipofuscin accumulation

Mutations in DNAJC5/CSPα are associated with adult neuronal ceroid lipofuscinosis (ANCL), a dominant-inherited neurodegenerative disease featuring lysosome-derived autofluorescent storage materials (AFSMs) termed lipofuscin. Functionally, DNAJC5 has been implicated in chaperoning synaptic proteins a...

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Detalles Bibliográficos
Autores principales:	Lee, Juhyung, Xu, Yue, Saidi, Layla, Xu, Miao, Zinsmaier, Konrad, Ye, Yihong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809949/ https://www.ncbi.nlm.nih.gov/pubmed/35506243 http://dx.doi.org/10.1080/15548627.2022.2065618

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