Cargando…

Impact of the COVID-19 pandemic and multiplex polymerase chain reaction test on outpatient antibiotic prescriptions for pediatric respiratory infection

This study aimed to evaluate the impact of the prolonged COVID-19 pandemic on outpatient antibiotic prescriptions for pediatric respiratory infections at an acute care hospital in Japan in order to direct future pediatric outpatient antibiotic stewardship. The impact of the COVID-19 pandemic and the...

Descripción completa

Detalles Bibliográficos
Autores principales: Kitagawa, Daisuke, Kitano, Taito, Furumori, Madoka, Suzuki, Soma, Shintani, Yui, Nishikawa, Hiroki, Suzuki, Rika, Yamamoto, Naohiro, Onaka, Masayuki, Nishiyama, Atsuko, Kasamatsu, Takehito, Shiraishi, Naoyuki, Suzuki, Yuki, Nakano, Akiyo, Nakano, Ryuichi, Yano, Hisakazu, Maeda, Koichi, Yoshida, Sayaka, Nakamura, Fumihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810151/
https://www.ncbi.nlm.nih.gov/pubmed/36595501
http://dx.doi.org/10.1371/journal.pone.0278932
_version_ 1784863249657757696
author Kitagawa, Daisuke
Kitano, Taito
Furumori, Madoka
Suzuki, Soma
Shintani, Yui
Nishikawa, Hiroki
Suzuki, Rika
Yamamoto, Naohiro
Onaka, Masayuki
Nishiyama, Atsuko
Kasamatsu, Takehito
Shiraishi, Naoyuki
Suzuki, Yuki
Nakano, Akiyo
Nakano, Ryuichi
Yano, Hisakazu
Maeda, Koichi
Yoshida, Sayaka
Nakamura, Fumihiko
author_facet Kitagawa, Daisuke
Kitano, Taito
Furumori, Madoka
Suzuki, Soma
Shintani, Yui
Nishikawa, Hiroki
Suzuki, Rika
Yamamoto, Naohiro
Onaka, Masayuki
Nishiyama, Atsuko
Kasamatsu, Takehito
Shiraishi, Naoyuki
Suzuki, Yuki
Nakano, Akiyo
Nakano, Ryuichi
Yano, Hisakazu
Maeda, Koichi
Yoshida, Sayaka
Nakamura, Fumihiko
author_sort Kitagawa, Daisuke
collection PubMed
description This study aimed to evaluate the impact of the prolonged COVID-19 pandemic on outpatient antibiotic prescriptions for pediatric respiratory infections at an acute care hospital in Japan in order to direct future pediatric outpatient antibiotic stewardship. The impact of the COVID-19 pandemic and the FilmArray Respiratory Panel (RP) on outpatient antibiotic prescriptions was assessed from January 2019 to December 2021 using an interrupted time series analysis of children <20 years. The overall antimicrobial prescription rate decreased from 38.7% to 22.4% from the pre-pandemic period to the pandemic. The pandemic (relative risk [RR] level, 0.97 [0.58–1.61]; P = 0.90; RR slope, 1.05 [0.95–1.17] per month; P = 0.310) and FilmArray RP (RR level, 0.90 [0.46–1.75]; P = 0.75; RR slope, 0.95 [0.85–1.06] per month; P = 0.330) had no significant effect on the monthly antibiotic prescription rates. The COVID-19 pandemic was not significantly related to the antibiotic prescription rate, suggesting that it did not impact physicians’ behavior toward antibiotic prescriptions. Replacing rapid antigen tests with the FilmArray RP introduced on December 1, 2020, did not affect the magnitude of the reduction in antibiotic prescription rate for pediatric respiratory infections.
format Online
Article
Text
id pubmed-9810151
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-98101512023-01-04 Impact of the COVID-19 pandemic and multiplex polymerase chain reaction test on outpatient antibiotic prescriptions for pediatric respiratory infection Kitagawa, Daisuke Kitano, Taito Furumori, Madoka Suzuki, Soma Shintani, Yui Nishikawa, Hiroki Suzuki, Rika Yamamoto, Naohiro Onaka, Masayuki Nishiyama, Atsuko Kasamatsu, Takehito Shiraishi, Naoyuki Suzuki, Yuki Nakano, Akiyo Nakano, Ryuichi Yano, Hisakazu Maeda, Koichi Yoshida, Sayaka Nakamura, Fumihiko PLoS One Research Article This study aimed to evaluate the impact of the prolonged COVID-19 pandemic on outpatient antibiotic prescriptions for pediatric respiratory infections at an acute care hospital in Japan in order to direct future pediatric outpatient antibiotic stewardship. The impact of the COVID-19 pandemic and the FilmArray Respiratory Panel (RP) on outpatient antibiotic prescriptions was assessed from January 2019 to December 2021 using an interrupted time series analysis of children <20 years. The overall antimicrobial prescription rate decreased from 38.7% to 22.4% from the pre-pandemic period to the pandemic. The pandemic (relative risk [RR] level, 0.97 [0.58–1.61]; P = 0.90; RR slope, 1.05 [0.95–1.17] per month; P = 0.310) and FilmArray RP (RR level, 0.90 [0.46–1.75]; P = 0.75; RR slope, 0.95 [0.85–1.06] per month; P = 0.330) had no significant effect on the monthly antibiotic prescription rates. The COVID-19 pandemic was not significantly related to the antibiotic prescription rate, suggesting that it did not impact physicians’ behavior toward antibiotic prescriptions. Replacing rapid antigen tests with the FilmArray RP introduced on December 1, 2020, did not affect the magnitude of the reduction in antibiotic prescription rate for pediatric respiratory infections. Public Library of Science 2023-01-03 /pmc/articles/PMC9810151/ /pubmed/36595501 http://dx.doi.org/10.1371/journal.pone.0278932 Text en © 2023 Kitagawa et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kitagawa, Daisuke
Kitano, Taito
Furumori, Madoka
Suzuki, Soma
Shintani, Yui
Nishikawa, Hiroki
Suzuki, Rika
Yamamoto, Naohiro
Onaka, Masayuki
Nishiyama, Atsuko
Kasamatsu, Takehito
Shiraishi, Naoyuki
Suzuki, Yuki
Nakano, Akiyo
Nakano, Ryuichi
Yano, Hisakazu
Maeda, Koichi
Yoshida, Sayaka
Nakamura, Fumihiko
Impact of the COVID-19 pandemic and multiplex polymerase chain reaction test on outpatient antibiotic prescriptions for pediatric respiratory infection
title Impact of the COVID-19 pandemic and multiplex polymerase chain reaction test on outpatient antibiotic prescriptions for pediatric respiratory infection
title_full Impact of the COVID-19 pandemic and multiplex polymerase chain reaction test on outpatient antibiotic prescriptions for pediatric respiratory infection
title_fullStr Impact of the COVID-19 pandemic and multiplex polymerase chain reaction test on outpatient antibiotic prescriptions for pediatric respiratory infection
title_full_unstemmed Impact of the COVID-19 pandemic and multiplex polymerase chain reaction test on outpatient antibiotic prescriptions for pediatric respiratory infection
title_short Impact of the COVID-19 pandemic and multiplex polymerase chain reaction test on outpatient antibiotic prescriptions for pediatric respiratory infection
title_sort impact of the covid-19 pandemic and multiplex polymerase chain reaction test on outpatient antibiotic prescriptions for pediatric respiratory infection
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810151/
https://www.ncbi.nlm.nih.gov/pubmed/36595501
http://dx.doi.org/10.1371/journal.pone.0278932
work_keys_str_mv AT kitagawadaisuke impactofthecovid19pandemicandmultiplexpolymerasechainreactiontestonoutpatientantibioticprescriptionsforpediatricrespiratoryinfection
AT kitanotaito impactofthecovid19pandemicandmultiplexpolymerasechainreactiontestonoutpatientantibioticprescriptionsforpediatricrespiratoryinfection
AT furumorimadoka impactofthecovid19pandemicandmultiplexpolymerasechainreactiontestonoutpatientantibioticprescriptionsforpediatricrespiratoryinfection
AT suzukisoma impactofthecovid19pandemicandmultiplexpolymerasechainreactiontestonoutpatientantibioticprescriptionsforpediatricrespiratoryinfection
AT shintaniyui impactofthecovid19pandemicandmultiplexpolymerasechainreactiontestonoutpatientantibioticprescriptionsforpediatricrespiratoryinfection
AT nishikawahiroki impactofthecovid19pandemicandmultiplexpolymerasechainreactiontestonoutpatientantibioticprescriptionsforpediatricrespiratoryinfection
AT suzukirika impactofthecovid19pandemicandmultiplexpolymerasechainreactiontestonoutpatientantibioticprescriptionsforpediatricrespiratoryinfection
AT yamamotonaohiro impactofthecovid19pandemicandmultiplexpolymerasechainreactiontestonoutpatientantibioticprescriptionsforpediatricrespiratoryinfection
AT onakamasayuki impactofthecovid19pandemicandmultiplexpolymerasechainreactiontestonoutpatientantibioticprescriptionsforpediatricrespiratoryinfection
AT nishiyamaatsuko impactofthecovid19pandemicandmultiplexpolymerasechainreactiontestonoutpatientantibioticprescriptionsforpediatricrespiratoryinfection
AT kasamatsutakehito impactofthecovid19pandemicandmultiplexpolymerasechainreactiontestonoutpatientantibioticprescriptionsforpediatricrespiratoryinfection
AT shiraishinaoyuki impactofthecovid19pandemicandmultiplexpolymerasechainreactiontestonoutpatientantibioticprescriptionsforpediatricrespiratoryinfection
AT suzukiyuki impactofthecovid19pandemicandmultiplexpolymerasechainreactiontestonoutpatientantibioticprescriptionsforpediatricrespiratoryinfection
AT nakanoakiyo impactofthecovid19pandemicandmultiplexpolymerasechainreactiontestonoutpatientantibioticprescriptionsforpediatricrespiratoryinfection
AT nakanoryuichi impactofthecovid19pandemicandmultiplexpolymerasechainreactiontestonoutpatientantibioticprescriptionsforpediatricrespiratoryinfection
AT yanohisakazu impactofthecovid19pandemicandmultiplexpolymerasechainreactiontestonoutpatientantibioticprescriptionsforpediatricrespiratoryinfection
AT maedakoichi impactofthecovid19pandemicandmultiplexpolymerasechainreactiontestonoutpatientantibioticprescriptionsforpediatricrespiratoryinfection
AT yoshidasayaka impactofthecovid19pandemicandmultiplexpolymerasechainreactiontestonoutpatientantibioticprescriptionsforpediatricrespiratoryinfection
AT nakamurafumihiko impactofthecovid19pandemicandmultiplexpolymerasechainreactiontestonoutpatientantibioticprescriptionsforpediatricrespiratoryinfection