Methodological approaches to optimize multiplex oral fluid SARS-CoV-2 IgG assay performance and correlation with serologic and neutralizing antibody responses

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BACKGROUND. Oral fluid (hereafter, saliva) is a non-invasive and attractive alternative to blood for SARS-CoV-2 IgG testing; however, the heterogeneity of saliva as a matrix poses challenges for immunoassay performance. OBJECTIVES. To optimize performance of a magnetic microparticle-based multiplex...

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Detalles Bibliográficos
Autores principales: Pisanic, Nora, Antar, Annukka A. R., Kruczynski, Kate, Rivera, Magdielis Gregory, Dhakal, Santosh, Spicer, Kristoffer, Randad, Pranay R., Pekosz, Andrew, Klein, Sabra L., Betenbaugh, Michael J., Detrick, Barbara, Clarke, William, Thomas, David L., Manabe, Yukari C., Heaney, Christopher D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810233/
https://www.ncbi.nlm.nih.gov/pubmed/36597525
http://dx.doi.org/10.1101/2022.12.22.22283858
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