T-cell cellular stress and reticulocyte signatures, but not loss of naïve T lymphocytes, characterize severe COVID-19 in older adults

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In children and younger adults up to 39 years of age, SARS-CoV-2 usually elicits mild symptoms that resemble the common cold. Disease severity increases with age starting at 30 and reaches astounding mortality rates that are ~330 fold higher in persons above 85 years of age compared to those 18–39 y...

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Detalles Bibliográficos
Autores principales: Jergović, Mladen, Watanabe, Makiko, Bhat, Ruchika, Coplen, Christopher P., Sonar, Sandip A., Wong, Rachel, Castaneda, Yvonne, Davidson, Lisa, Kala, Mrinalini, Wilson, Rachel C., Twigg, Homer L., Knox, Kenneth, Erickson, Heidi E., Weinkauf, Craig C., Bime, Christian, Bixby, Billie A., Parthasarathy, Sairam, Mosier, Jarrod M., LaFleur, Bonnie J., Bhattacharya, Deepta, Nikolich, Janko Ž.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810235/
https://www.ncbi.nlm.nih.gov/pubmed/36597549
http://dx.doi.org/10.1101/2022.12.21.521463
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