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Heritability enrichment in context-specific regulatory networks improves phenotype-relevant tissue identification

Systems genetics holds the promise to decipher complex traits by interpreting their associated SNPs through gene regulatory networks derived from comprehensive multi-omics data of cell types, tissues, and organs. Here, we propose SpecVar to integrate paired chromatin accessibility and gene expressio...

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Detalles Bibliográficos
Autores principales:	Feng, Zhanying, Duren, Zhana, Xin, Jingxue, Yuan, Qiuyue, He, Yaoxi, Su, Bing, Wong, Wing Hung, Wang, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Computational and Systems Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810332/ https://www.ncbi.nlm.nih.gov/pubmed/36525361 http://dx.doi.org/10.7554/eLife.82535

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