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B7-H3: A Useful Emerging Diagnostic Marker for Colon Cancer

BACKGROUND: Colon cancer is the second most common malignancy causing the majority of cancer-related deaths. B7-H3 concentrations have drawn major interest as possible diagnostic biomarkers of cancer. The aim of this study was to measure the preoperative serum B7-H3 levels and to determine those tha...

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Autores principales: Bostanci, Ozgur, Sayin, Pinar, Kiziltan, Remzi, Algul, Sermin, Aydin, Mehmet Akif, Kemik, Ozgur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810404/
https://www.ncbi.nlm.nih.gov/pubmed/36605103
http://dx.doi.org/10.1155/2022/1523338
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author Bostanci, Ozgur
Sayin, Pinar
Kiziltan, Remzi
Algul, Sermin
Aydin, Mehmet Akif
Kemik, Ozgur
author_facet Bostanci, Ozgur
Sayin, Pinar
Kiziltan, Remzi
Algul, Sermin
Aydin, Mehmet Akif
Kemik, Ozgur
author_sort Bostanci, Ozgur
collection PubMed
description BACKGROUND: Colon cancer is the second most common malignancy causing the majority of cancer-related deaths. B7-H3 concentrations have drawn major interest as possible diagnostic biomarkers of cancer. The aim of this study was to measure the preoperative serum B7-H3 levels and to determine those that are replaced in colon cancer. METHOD: We measured preoperative serum B7-H3 concentrations of 90 patients aged 57-69 years diagnosed with colon cancer and 50 age-matched healthy individuals. B7-H3 levels were determined using the sandwich enzyme-linked immunosorbent assay (ELISA). Patients were categorized by stage based on the TNM staging system, and the serum levels of B7-H3 were compared between patients with different TNM stages. RESULT: No statistically significant difference was found between the patient and control groups in terms of age and gender. Preoperative serum B7-H3 levels were statistically significantly higher in patients with colon cancer than in the healthy group (p < 0.001). Preoperative serum B7-H3 concentration of the stage IV patients was significantly higher than those of the patients with stage I and stage II disease. In addition, higher serum B7-H3 levels were associated with lymph node status and distant metastasis in colon cancer. CONCLUSION: We showed that B7-H3 is highly expressed in colon cancer and can be used as a candidate diagnostic biomarker and a potential target in colon cancer in future.
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spelling pubmed-98104042023-01-04 B7-H3: A Useful Emerging Diagnostic Marker for Colon Cancer Bostanci, Ozgur Sayin, Pinar Kiziltan, Remzi Algul, Sermin Aydin, Mehmet Akif Kemik, Ozgur Biomed Res Int Research Article BACKGROUND: Colon cancer is the second most common malignancy causing the majority of cancer-related deaths. B7-H3 concentrations have drawn major interest as possible diagnostic biomarkers of cancer. The aim of this study was to measure the preoperative serum B7-H3 levels and to determine those that are replaced in colon cancer. METHOD: We measured preoperative serum B7-H3 concentrations of 90 patients aged 57-69 years diagnosed with colon cancer and 50 age-matched healthy individuals. B7-H3 levels were determined using the sandwich enzyme-linked immunosorbent assay (ELISA). Patients were categorized by stage based on the TNM staging system, and the serum levels of B7-H3 were compared between patients with different TNM stages. RESULT: No statistically significant difference was found between the patient and control groups in terms of age and gender. Preoperative serum B7-H3 levels were statistically significantly higher in patients with colon cancer than in the healthy group (p < 0.001). Preoperative serum B7-H3 concentration of the stage IV patients was significantly higher than those of the patients with stage I and stage II disease. In addition, higher serum B7-H3 levels were associated with lymph node status and distant metastasis in colon cancer. CONCLUSION: We showed that B7-H3 is highly expressed in colon cancer and can be used as a candidate diagnostic biomarker and a potential target in colon cancer in future. Hindawi 2022-12-27 /pmc/articles/PMC9810404/ /pubmed/36605103 http://dx.doi.org/10.1155/2022/1523338 Text en Copyright © 2022 Ozgur Bostanci et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bostanci, Ozgur
Sayin, Pinar
Kiziltan, Remzi
Algul, Sermin
Aydin, Mehmet Akif
Kemik, Ozgur
B7-H3: A Useful Emerging Diagnostic Marker for Colon Cancer
title B7-H3: A Useful Emerging Diagnostic Marker for Colon Cancer
title_full B7-H3: A Useful Emerging Diagnostic Marker for Colon Cancer
title_fullStr B7-H3: A Useful Emerging Diagnostic Marker for Colon Cancer
title_full_unstemmed B7-H3: A Useful Emerging Diagnostic Marker for Colon Cancer
title_short B7-H3: A Useful Emerging Diagnostic Marker for Colon Cancer
title_sort b7-h3: a useful emerging diagnostic marker for colon cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810404/
https://www.ncbi.nlm.nih.gov/pubmed/36605103
http://dx.doi.org/10.1155/2022/1523338
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