Cargando…

6-Shogaol and 10-Shogaol Synergize Curcumin in Ameliorating Proinflammatory Mediators via the Modulation of TLR4/TRAF6/MAPK and NFκB Translocation

Extensive research supported the therapeutic potential of curcumin, a naturally occurring compound, as a promising cytokine-suppressive anti-inflammatory drug. This study aimed to investigate the synergistic anti-inflammatory and anti-cytokine activities by combining 6-shogaol and 10-shogaol to curc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Xian, Al-Khazaleh, Ahmad, Afzal, Sualiha, Kao, Ming-Hui (Tim), Münch, Gerald, Wohlmuth, Hans, Leach, David, Low, Mitchell, Li, Chun Guang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Society of Applied Pharmacology 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810444/ https://www.ncbi.nlm.nih.gov/pubmed/36319441 http://dx.doi.org/10.4062/biomolther.2022.039

Ejemplares similares

Glucuronidation of [6]-shogaol, [8]-shogaol and [10]-shogaol by human tissues and expressed UGT enzymes: identification of UGT2B7 as the major contributor
por: He, Liangliang, et al.
Publicado: (2018)

Anticancer perspective of 6-shogaol: anticancer properties, mechanism of action, synergism and delivery system
por: Jia, Yaoxia, et al.
Publicado: (2023)

Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes
por: Bischoff-Kont, Iris, et al.
Publicado: (2021)

Synergistic Anti-Inflammatory Activity of Ginger and Turmeric Extracts in Inhibiting Lipopolysaccharide and Interferon-γ-Induced Proinflammatory Mediators
por: Zhou, Xian, et al.
Publicado: (2022)

6-Shogaol attenuated ethylene glycol and aluminium chloride induced urolithiasis and renal injuries in rodents
por: Afzal, Muhammad, et al.
Publicado: (2021)

Effect of 6-Shogaol on the Glucose Uptake and Survival of HT1080 Fibrosarcoma Cells
por: Romero-Arias, Angie C., et al.
Publicado: (2019)

6-Shogaol Mitigates Sepsis-Associated Hepatic Injury through Transcriptional Regulation
por: Guo, Xiaoxuan, et al.
Publicado: (2021)

Histone Deacetylase Inhibitory Activity and Antiproliferative Potential of New [6]-Shogaol Derivatives
por: Phaosiri, Chanokbhorn, et al.
Publicado: (2022)

6-shogaol is a potential treatment for Head and Neck Squamous Cell Carcinoma
por: Hsu, Cheng-Ming, et al.
Publicado: (2023)

The possibility of using shogaol for treatment of ulcerative colitis
por: Hassan, Snur MA, et al.
Publicado: (2018)

Synergistic Inhibition of Pro-Inflammatory Pathways by Ginger and Turmeric Extracts in RAW 264.7 Cells
por: Zhou, Xian, et al.
Publicado: (2022)

Anti-inflammatory effect and signaling mechanism of 8-shogaol and 10-shogaol in a dextran sodium sulfate-induced colitis mouse model
por: Kim, Ha-Rim, et al.
Publicado: (2023)

6-Shogaol Overcomes Gefitinib Resistance via ER Stress in Ovarian Cancer Cells
por: Kim, Tae Woo, et al.
Publicado: (2023)

Effects of 6-Shogaol on Glucose Uptake and Intestinal Barrier Integrity in Caco-2 Cells
por: Jiao, Wenya, et al.
Publicado: (2023)

Antibiofilm and Antivirulence Activities of 6-Gingerol and 6-Shogaol Against Candida albicans Due to Hyphal Inhibition
por: Lee, Jin-Hyung, et al.
Publicado: (2018)

Neuroprotective Effects of 6-Shogaol and Its Metabolite, 6-Paradol, in a Mouse Model of Multiple Sclerosis
por: Sapkota, Arjun, et al.
Publicado: (2019)

6-Shogaol reduced chronic inflammatory response in the knees of rats treated with complete Freund's adjuvant
por: Levy, Arkene SA, et al.
Publicado: (2006)

Optimization of Extraction Conditions for the 6-Shogaol-rich Extract from Ginger (Zingiber officinale Roscoe)
por: Ok, Seon, et al.
Publicado: (2012)

Identification and characterization of [6]-shogaol from ginger as inhibitor of vascular smooth muscle cell proliferation
por: Liu, Rongxia, et al.
Publicado: (2015)

Anticancer effects of 6-shogaol via the AKT signaling pathway in oral squamous cell carcinoma
por: HUANG, Hai, et al.
Publicado: (2021)

Is 6-Shogaol an Effective Phytochemical for Patients With Lower-risk Myelodysplastic Syndrome? A Narrative Review
por: Ooi, Soo Liang, et al.
Publicado: (2021)

Comparing the effects of microwave radiation on 6-gingerol and 6-shogaol from ginger rhizomes (Zingiber officinale Rosc)
por: Teng, Hui, et al.
Publicado: (2019)

Quantitation of 6-, 8- and 10-Gingerols and 6-Shogaol in Human Plasma by High-Performance Liquid Chromatography with Electrochemical Detection
por: Zick, Suzanna M., et al.
Publicado: (2010)

6-Shogaol-Rich Extract from Ginger Up-Regulates the Antioxidant Defense Systems in Cells and Mice
por: Bak, Min-Ji, et al.
Publicado: (2012)

6-Shogaol attenuates LPS-induced inflammation in BV2 microglia cells by activating PPAR-γ
por: Han, Qinghe, et al.
Publicado: (2017)

Orally Administered Natural Lipid Nanoparticle-Loaded 6-Shogaol Shapes the Anti-Inflammatory Microbiota and Metabolome
por: Yang, Chunhua, et al.
Publicado: (2021)

[6]-Shogaol Attenuates Oxaliplatin-Induced Allodynia through Serotonergic Receptors and GABA in the Spinal Cord in Mice
por: Kim, Suyong, et al.
Publicado: (2022)

Involvement of the Spinal Serotonergic System in the Analgesic Effect of [6]-Shogaol in Oxaliplatin-Induced Neuropathic Pain in Mice
por: Gang, Juan, et al.
Publicado: (2023)

Correction: 6-Shogaol attenuates LPS-induced inflammation in BV2 microglia cells by activating PPAR-γ
por: Han, Qinghe, et al.
Publicado: (2018)

Beneficial effects of 6-shogaol on hyperglycemia, islet morphology and apoptosis in some tissues of streptozotocin-induced diabetic mice
por: Yi, Jun-Koo, et al.
Publicado: (2019)

Ginger Constituent 6-Shogaol Inhibits Inflammation- and Angiogenesis-Related Cell Functions in Primary Human Endothelial Cells
por: Bischoff-Kont, Iris, et al.
Publicado: (2022)

Ginger Constituent 6-Shogaol Attenuates Vincristine-Induced Activation of Mouse Gastroesophageal Vagal Afferent C-Fibers
por: Patil, Mayur J., et al.
Publicado: (2022)

Formation of 6-, 8- and 10-Shogaol in Ginger through Application of Different Drying Methods: Altered Antioxidant and Antimicrobial Activity
por: Ghasemzadeh, Ali, et al.
Publicado: (2018)

Protective Effects of 6-Shogaol, an Active Compound of Ginger, in a Murine Model of Cisplatin-Induced Acute Kidney Injury
por: Gwon, Mi-Gyeong, et al.
Publicado: (2021)

6-Shogaol as a Novel Thioredoxin Reductase Inhibitor Induces Oxidative-Stress-Mediated Apoptosis in HeLa Cells
por: Peng, Shoujiao, et al.
Publicado: (2023)

6-Shogaol Protects against Oxidized LDL-Induced Endothelial Injruries by Inhibiting Oxidized LDL-Evoked LOX-1 Signaling
por: Wang, Yun kai, et al.
Publicado: (2013)

Pharmacokinetics of 10-gingerol and 6-shogaol in the plasma of healthy subjects treated with red ginger (Zingiber officinale var. Rubrum) suspension
por: Levita, Jutti, et al.
Publicado: (2018)

The antagonism of 6-shogaol in high-glucose-activated NLRP3 inflammasome and consequent calcification of human artery smooth muscle cells
por: Chen, Te-Chuan, et al.
Publicado: (2020)

6-Shogaol Exhibits a Promoting Effect with Tax via Binding HSP60 in Non-Small-Cell Lung Cancer
por: Mulati, Shulipan, et al.
Publicado: (2022)

6-Shogaol Exhibits Anti-viral and Anti-inflammatory Activity in COVID-19-Associated Inflammation by Regulating NLRP3 Inflammasomes
por: Kode, Jyoti, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_keag0gfgovg9b14vvavshjsjoo