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Factors influencing decision making and antibiotic prescribing patterns for the treatment of carbapenem-resistant Enterobacteriaceae (CRE) among non-infectious physicians in Thailand: a qualitative study

The treatment of carbapenem-resistant Enterobacteriaceae (CRE) is diverse in each region due to the difference in local resistant patterns of CRE. We aimed to explore how physicians in Thailand decide on selection options for treating CRE infections. In this study, 25 physicians who were not infecti...

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Autores principales: Soontaros, Suluck, Leelakanok, Nattawut, Mepradis, Yuttaphum, Auamnoy, Titinun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Clinical Pharmacology and Therapeutics 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810490/
https://www.ncbi.nlm.nih.gov/pubmed/36632079
http://dx.doi.org/10.12793/tcp.2022.30.e18
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author Soontaros, Suluck
Leelakanok, Nattawut
Mepradis, Yuttaphum
Auamnoy, Titinun
author_facet Soontaros, Suluck
Leelakanok, Nattawut
Mepradis, Yuttaphum
Auamnoy, Titinun
author_sort Soontaros, Suluck
collection PubMed
description The treatment of carbapenem-resistant Enterobacteriaceae (CRE) is diverse in each region due to the difference in local resistant patterns of CRE. We aimed to explore how physicians in Thailand decide on selection options for treating CRE infections. In this study, 25 physicians who were not infectious disease (ID) specialists participated in this semi-structured in-depth interview. We found that they, in general, did not provide empiric antibiotics for the treatment of CRE. However, some patients, e.g., those with prior carbapenems exposure may have brought CRE to physicians’ attention. ID specialists played critical roles in both empiric and specific CRE treatment. There were multiple scenarios when CRE management deviated from recommendations, especially when physicians perceived that the evidence that supported the recommendations was weak. Several supportive factors, challenges, and improvements were also suggested. In conclusion, ID specialists, adequate information, and consistent implementation of infectious control policy are crucial to the treatment and prevention of CRE infection.
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spelling pubmed-98104902023-01-10 Factors influencing decision making and antibiotic prescribing patterns for the treatment of carbapenem-resistant Enterobacteriaceae (CRE) among non-infectious physicians in Thailand: a qualitative study Soontaros, Suluck Leelakanok, Nattawut Mepradis, Yuttaphum Auamnoy, Titinun Transl Clin Pharmacol Original Article The treatment of carbapenem-resistant Enterobacteriaceae (CRE) is diverse in each region due to the difference in local resistant patterns of CRE. We aimed to explore how physicians in Thailand decide on selection options for treating CRE infections. In this study, 25 physicians who were not infectious disease (ID) specialists participated in this semi-structured in-depth interview. We found that they, in general, did not provide empiric antibiotics for the treatment of CRE. However, some patients, e.g., those with prior carbapenems exposure may have brought CRE to physicians’ attention. ID specialists played critical roles in both empiric and specific CRE treatment. There were multiple scenarios when CRE management deviated from recommendations, especially when physicians perceived that the evidence that supported the recommendations was weak. Several supportive factors, challenges, and improvements were also suggested. In conclusion, ID specialists, adequate information, and consistent implementation of infectious control policy are crucial to the treatment and prevention of CRE infection. Korean Society for Clinical Pharmacology and Therapeutics 2022-12 2022-12-12 /pmc/articles/PMC9810490/ /pubmed/36632079 http://dx.doi.org/10.12793/tcp.2022.30.e18 Text en Copyright © 2022 Translational and Clinical Pharmacology https://creativecommons.org/licenses/by-nc/4.0/It is identical to the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/).
spellingShingle Original Article
Soontaros, Suluck
Leelakanok, Nattawut
Mepradis, Yuttaphum
Auamnoy, Titinun
Factors influencing decision making and antibiotic prescribing patterns for the treatment of carbapenem-resistant Enterobacteriaceae (CRE) among non-infectious physicians in Thailand: a qualitative study
title Factors influencing decision making and antibiotic prescribing patterns for the treatment of carbapenem-resistant Enterobacteriaceae (CRE) among non-infectious physicians in Thailand: a qualitative study
title_full Factors influencing decision making and antibiotic prescribing patterns for the treatment of carbapenem-resistant Enterobacteriaceae (CRE) among non-infectious physicians in Thailand: a qualitative study
title_fullStr Factors influencing decision making and antibiotic prescribing patterns for the treatment of carbapenem-resistant Enterobacteriaceae (CRE) among non-infectious physicians in Thailand: a qualitative study
title_full_unstemmed Factors influencing decision making and antibiotic prescribing patterns for the treatment of carbapenem-resistant Enterobacteriaceae (CRE) among non-infectious physicians in Thailand: a qualitative study
title_short Factors influencing decision making and antibiotic prescribing patterns for the treatment of carbapenem-resistant Enterobacteriaceae (CRE) among non-infectious physicians in Thailand: a qualitative study
title_sort factors influencing decision making and antibiotic prescribing patterns for the treatment of carbapenem-resistant enterobacteriaceae (cre) among non-infectious physicians in thailand: a qualitative study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810490/
https://www.ncbi.nlm.nih.gov/pubmed/36632079
http://dx.doi.org/10.12793/tcp.2022.30.e18
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