SHP-2 and PD-1-SHP-2 signaling regulate myeloid cell differentiation and antitumor responses

The inhibitory receptor PD-1 suppresses T cell activation by recruiting the phosphatase SHP-2. However, mice with a T-cell-specific deletion of SHP-2 do not have improved antitumor immunity. Here we showed that mice with conditional targeting of SHP-2 in myeloid cells, but not in T cells, had dimini...

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Detalles Bibliográficos
Autores principales: Christofides, Anthos, Katopodi, Xanthi-Lida, Cao, Carol, Karagkouni, Dimitra, Aliazis, Konstantinos, Yenyuwadee, Sasitorn, Aksoylar, Halil-Ibrahim, Pal, Rinku, Mahmoud, Mohamed A. A., Strauss, Laura, Tijaro-Ovalle, Natalia M., Boon, Louis, Asara, John, Vlachos, Ioannis S., Patsoukis, Nikolaos, Boussiotis, Vassiliki A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810534/
https://www.ncbi.nlm.nih.gov/pubmed/36581713
http://dx.doi.org/10.1038/s41590-022-01385-x

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