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Human mitochondria require mtRF1 for translation termination at non-canonical stop codons

The mitochondrial translation machinery highly diverged from its bacterial counterpart. This includes deviation from the universal genetic code, with AGA and AGG codons lacking cognate tRNAs in human mitochondria. The locations of these codons at the end of COX1 and ND6 open reading frames, respecti...

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Detalles Bibliográficos
Autores principales:	Krüger, Annika, Remes, Cristina, Shiriaev, Dmitrii Igorevich, Liu, Yong, Spåhr, Henrik, Wibom, Rolf, Atanassov, Ilian, Nguyen, Minh Duc, Cooperman, Barry S., Rorbach, Joanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810596/ https://www.ncbi.nlm.nih.gov/pubmed/36596788 http://dx.doi.org/10.1038/s41467-022-35684-6

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